Therapeutic vascular growth in the heart.

Vascular biology (Bristol, England) Pub Date : 2019-03-28 eCollection Date: 2019-01-01 DOI:10.1530/VB-19-0006
Ebba Brakenhielm, Vincent Richard
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引用次数: 2

Abstract

Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging. In this mini review, we briefly present the current main approaches applied to improve pro-angiogenic therapies. Specific examples from research on therapeutic cardiac angiogenesis and arteriogenesis will be discussed, and finally some suggestions for future therapeutic developments will be presented.

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治疗性心脏血管生长。
尽管在过去几十年的临床前研究中做出了巨大的努力,但在缺血性疾病患者中,治疗性血管生成以生长稳定和功能血管的临床转化仍然具有挑战性。在这篇综述中,我们简要介绍了目前用于改善促血管生成治疗的主要方法。本文将讨论治疗性心脏血管生成和动脉生成的具体研究实例,并对未来的治疗发展提出建议。
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