A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study.

Abstract

Background: T₂ relaxation-based magnetic resonance imaging (MRI) signals may provide onset time for acute ischemic strokes with an unknown onset. The ability of visual and quantitative MRI-based methods in a cohort of hyperacute ischemic stroke patients was studied.

Methods: A total of 35 patients underwent 3T (3 Tesla) MRI (<9-hour symptom onset). Diffusion-weighted (DWI), apparent diffusion coefficient (ADC), T₁-weighted (T₁w), T₂-weighted (T₂w), and T₂ relaxation time (T₂) images were acquired. T₂-weighted fluid attenuation inversion recovery (FLAIR) images were acquired for 17 of these patients. Image intensity ratios of the average intensities in ischemic and non-ischemic reference regions were calculated for ADC, DWI, T₂w, T₂ relaxation, and FLAIR images, and optimal image intensity ratio cut-offs were determined. DWI and FLAIR images were assessed visually for DWI/FLAIR mismatch.

Results: The T₂ relaxation time image intensity ratio was the only parameter with significant correlation with stroke duration (r = 0.49, P = .003), an area under the receiver operating characteristic curve (AUC = 0.77, P < .0001), and an optimal cut-off (T₂ ratio = 1.072) that accurately identified patients within the 4.5-hour thrombolysis treatment window with sensitivity of 0.74 and specificity of 0.74. In the patients with the additional FLAIR, areas under the precision-recall-gain curve (AUPRG) and F₁ scores showed that the T₂ relaxation time ratio (AUPRG = 0.60, F₁ = 0.73) performed considerably better than the FLAIR ratio (AUPRG = 0.39, F₁ = 0.57) and the visual DWI/FLAIR mismatch (F₁ = 0.25).

Conclusions: Quantitative T₂ relaxation time is the preferred MRI parameter in the assessment of patients with unknown onset for treatment stratification.