High cardiovascular risk of patients with type 2 diabetes is only partially attributed to angiographic burden of atherosclerosis.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes & Vascular Disease Research Pub Date : 2020-09-01 DOI:10.1177/1479164120953612

Simone Battermann, Andrea Milzi, Rosalia Dettori, Kathrin Burgmaier, Nikolaus Marx, Mathias Burgmaier, Sebastian Reith

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引用次数: 5

Abstract

Background: Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events and present more severe coronary artery disease (CAD). The Gensini and COURAGE scores are established angiographic instruments to assess CAD severity, which may also predict future cardiovascular risk. However, it is unclear if these scores are able to depict the increased risk of patients with T2DM and stable CAD (T2DM-SAP).

Methods: We performed quantitative coronary angiography and assessed the Gensini and COURAGE scores in 124 patients with T2DM-SAP. Angiographic data were compared to patients with stable angina without T2DM (Non-DM-SAP, n = 74), and to patients with acute coronary syndrome and T2DM (T2DM-ACS, n = 53).

Results: T2DM-SAP patients had similar Gensini and COURAGE-scores compared to Non-DM-SAP-patients (Gensini: 14.44 ± 27.34 vs 11.49 ± 26.99, p = 0.465; COURAGE: 3.48 ± 4.49 vs 3.60 ± 4.72, p = 0.854). In contrast, T2DM-SAP patients had significantly lower Gensini (14.44 ± 27.34 vs 30.94 ± 48.74, p = 0.003) and lower COURAGE (3.48 ± 4.49 vs 5.30 ± 4.63, p = 0.016) scores compared to T2DM-ACS-patients.

Conclusion: Both the Gensini and the COURAGE score fail to predict the high cardiovascular risk of patients with T2DM-SAP. Therefore, these scores should be used with caution in the assessment of future risk of patients with T2DM. However, among T2DM-ACS patients, both scores are increased, reflecting the high cardiovascular risk in this patient population.

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2型糖尿病患者的高心血管风险仅部分归因于动脉粥样硬化的血管造影负担。

背景:2型糖尿病(T2DM)患者发生心血管事件的风险较高，且冠状动脉疾病(CAD)更为严重。Gensini和COURAGE评分是评估CAD严重程度的血管造影工具，也可以预测未来的心血管风险。然而，目前尚不清楚这些评分是否能够描述T2DM和稳定型CAD (T2DM- sap)患者的风险增加。方法:我们对124例T2DM-SAP患者进行定量冠状动脉造影并评估Gensini和COURAGE评分。将血管造影数据与无T2DM的稳定型心绞痛患者(Non-DM-SAP, n = 74)和急性冠脉综合征合并T2DM患者(T2DM- acs, n = 53)进行比较。结果:T2DM-SAP患者Gensini和courage评分与非dm - sap患者相似(Gensini: 14.44±27.34 vs 11.49±26.99,p = 0.465;勇气:3.48±4.49 vs 3.60±4.72,p = 0.854)。与t2dm - acs患者相比，T2DM-SAP患者Gensini评分(14.44±27.34比30.94±48.74,p = 0.003)和COURAGE评分(3.48±4.49比5.30±4.63,p = 0.016)明显低于t2dm - acs患者。结论:Gensini评分和COURAGE评分均不能预测T2DM-SAP患者的高心血管风险。因此，在评估2型糖尿病患者的未来风险时，应谨慎使用这些评分。然而，在T2DM-ACS患者中，两项评分均升高，反映了该患者人群的心血管风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)