No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

Elgar Susanne Quabius , Asita Fazel , Christopher Knieling , Stephan Gebhardt , Martin Laudien , Crystal Moore , André Kühnel , Florian Hoppe , Robert Mlynski , Alessa Heinrichs , Alexander Fabian , Markus Hoffmann
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引用次数: 7

Abstract

HPV-infection in patients with HNSCC is reportedly correlated with sexual behavior, age, and tobacco/alcohol-consumption. HPV-infections of the oral cavity are regarded as sexually transmitted. Comparable data of patient populations outside the U.S. are sparse or missing.

Questionnaires regarding sexual behavior, education tobacco- and alcohol-consumption, were given to 28 patients with tonsillar hyperplasia (H) and 128 patients with tonsillar carcinomas (CA), all with tissue-typed HPV-DNA-status performing PCR. Answers were correlated among groups and HPV-status.

106 questionnaires were analyzed. Comparisons between H- (n = 25) and CA- (n = 81) patients showed that CA-patients were older (61.1yrs ± 9.3) than H-patients (45.2yrs ± 11.9; p < 0.0001; Student's t-test); had a lower educational level (p = 0.0095); and lower number of sexual partners (p = 0.0222; Fisher's exact test). All groups showed a significant correlation between smoking and lack of HPV-DNA-positivity (p = 0.001). Further Fisher's exact tests and logistic regression analysis revealed in all 106 patients no significant correlations between tissue-HPV-status and the analyzed parameters.

Despite the limited sample size, we were able to confirm the established correlation between smoking and tissue-HPV-status. The correlation between sexual behavior and HPV-infection was not confirmed. No consensus exists in the literature about the latter. Our data does not support the strict classification of oral HPV-infections and HPV-driven HNSCCs as STDs.

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德国北部人群扁桃体组织中HPV状态与患者性行为之间无关联——HPV自然史与HPV驱动癌变之间联系的关键观点
据报道,HNSCC患者的hpv感染与性行为、年龄和吸烟/饮酒有关。口腔hpv感染被认为是性传播。美国以外的患者群体的可比数据很少或缺失。对28例扁桃体增生(H)患者和128例扁桃体癌(CA)患者进行了关于性行为、教育、烟草和酒精消费的问卷调查,所有患者都具有组织型hpv - dna状态,并进行了PCR。答案在各组和hpv感染状况之间存在相关性。分析了106份问卷。H-患者(n = 25)与CA-患者(n = 81)的比较表明,CA患者(61.1±9.3岁)比H-患者(45.2±11.9岁)年龄大;p & lt;0.0001;学生的学习任务);受教育程度较低(p = 0.0095);性伴侣数量较低(p = 0.0222;费雪精确检验)。所有组均显示吸烟与缺乏hpv - dna阳性之间存在显著相关性(p = 0.001)。进一步的Fisher精确检验和逻辑回归分析显示,在所有106例患者中,组织hpv状态与分析参数之间没有显著相关性。尽管样本量有限,但我们能够确认吸烟与组织hpv状态之间的既定相关性。性行为与hpv感染之间的相关性尚未得到证实。关于后者,文献中没有共识。我们的数据不支持口腔hpv感染和hpv驱动的HNSCCs作为性病的严格分类。
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期刊介绍: The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.
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