Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia.

4区医学 Q4 Medicine BMC Medical Genetics Pub Date : 2020-10-02 DOI:10.1186/s12881-020-01132-9

Xiaoqian Fu, Guofu Zhang, Yansong Liu, Ling Zhang, Fuquan Zhang, Conghua Zhou

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引用次数: 5

Abstract

Background: Schizophrenia is a severe, heritable, and refractory psychiatric disorder. Several studies have shown that the disrupted in schizophrenia 1 (DISC1) gene is closely associated with schizophrenia by its role in neuronal morphology, synaptic function, brain development, and dopamine homeostasis etc. This study intended to investigate the expression levels of DISC1 gene in schizophrenia patients compared with healthy controls, and the expression variation of DISC1 gene before and after antipsychotic treatment in schizophrenia patients.

Methods: In this study, we compared DISC1 expression levels in blood of 48 healthy controls, and 32 schizophrenia patients before and after 12 weeks of antipsychotic treatment using real-time quantitative PCR (RT-qPCR) analysis.

Results: The expression levels of DISC1 gene in peripheral blood mononuclear cells of schizophrenia patients before antipsychotic treatment were higher than those in healthy controls (P < 0.01); whereas after antipsychotic treatment, the expression levels of DISC1 gene in peripheral blood mononuclear cells of schizophrenia patients still remained increased (P < 0.01).

Conclusions: Our study provided further support for the involvement of DISC1 in the development of schizophrenia.

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精神分裂症患者外周血中DISC1基因表达的改变。

背景:精神分裂症是一种严重的、遗传性的、难治性的精神疾病。多项研究表明，DISC1基因在神经形态、突触功能、大脑发育、多巴胺稳态等方面与精神分裂症密切相关。本研究旨在探讨精神分裂症患者中DISC1基因与健康对照的表达水平，以及精神分裂症患者抗精神病药物治疗前后DISC1基因的表达变化。方法:采用实时荧光定量PCR (RT-qPCR)方法，比较48例健康对照和32例精神分裂症患者在抗精神病药物治疗12周前后血液中DISC1的表达水平。结果:精神分裂症患者抗精神病药物治疗前外周血单个核细胞中DISC1基因的表达水平高于健康对照组(P)。结论:本研究进一步支持了DISC1参与精神分裂症的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Genetics 医学-遗传学

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0.00%

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审稿时长

12 months

期刊介绍： BMC Medical Genetics is an open access journal publishing original peer-reviewed research articles in the effects of genetic variation in individuals, families and among populations in relation to human health and disease. Note: BMC Medical Genetics is now closed. This journal has merged with BMC Medical Genomics, a broad-scope, open access community journal for all medical genetics and genomics research.