Intra-articular hyaluronic acid injection vs. atorvastatin; which treatment is more effective in controlling symptoms of knee osteoarthritis? A clinical trial.
Mohammad Hasan Jokar, Zahra Mirfeizi, Hamzeh Zarei, Kamila Hashemzadeh
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Abstract
Background: Knee osteoarthritis is a disease of the elderly population. Two of the widely used treatment options for knee osteoarthritis is administration of oral atorvastatin and intra articular hyaluronic acid. This study was designed to compare the effects of oral atorvastatin and intra articular Hyaluronic acid in patients with knee osteoarthritis.
Method: This study was conducted under the approval of Mashhad University of medical sciences ethic committee. Seventy patients with knee OA were divided randomly into two groups; thirty five subjects were given intra articular Hyaluronic acid injections weekly for three weeks and 35 were given atorvastatin 40 milligrams orally daily for 6 months. WOMAC questioner was filled for each patient at the beginning of the study and every month up to 6 months. Data were analyzed with SPSS version 16.
Results: Enrolled subjects were consisted of 28 males (40%) and 42 females (60%), and their mean age was 57.9±1.1 years. Study groups were similar regarding gender and age distribution (P=0.626, P=0.710, respectively) significant difference between groups regarding sex (P=0.626). Mean age of patients was 57.9±1.1 years. Groups mean age did not differ significantly (P=0.710). According to WOMAC questionnaire, pain score in the second month after injection was significantly lower in the Hyaluronic acid group compared with atorvastatin (P<0.001). Function score in the second month after injection was significantly lower in the Hyaluronic acid group compared with atorvastatin (P<0.001). These differences were absent in the following months.
Conclusion: Compared to atorvastatin group, significant improvements in pain symptoms and physical function of knee OA patients were observed in intra articular Hyaluronic acid treatment group in the second month after treatment. But this improvement did not last through the following months.
背景:膝关节骨性关节炎是老年人的常见病。两种广泛使用的治疗选择是口服阿托伐他汀和关节内透明质酸。本研究旨在比较口服阿托伐他汀和关节内透明质酸治疗膝骨关节炎的效果。方法:本研究经马什哈德医科大学伦理委员会批准进行。70例膝关节OA患者随机分为两组;35名受试者每周接受关节内透明质酸注射，持续3周，35名受试者每天口服阿托伐他汀40毫克，持续6个月。每位患者在研究开始时填写WOMAC问卷，每个月填写一次，直至6个月。数据采用SPSS version 16进行分析。结果:入组受试者男性28人(40%)，女性42人(60%)，平均年龄57.9±1.1岁。研究组性别和年龄分布相似(P=0.626, P=0.710)，性别组间差异有统计学意义(P=0.626)。患者平均年龄57.9±1.1岁。各组平均年龄差异无统计学意义(P=0.710)。根据WOMAC问卷调查，透明质酸组注射后第2个月疼痛评分明显低于阿托伐他汀组(p)。结论:与阿托伐他汀组相比，关节内注射透明质酸组治疗后第2个月膝关节OA患者的疼痛症状和身体功能均有显著改善。但这种改善并没有持续到接下来的几个月。
期刊介绍：
Acta Reumatólogica Portuguesa is a scientific peer reviewed journal covering all aspects of rheumatic diseases and related to Rheumatology. The journal publishes original articles, reviews, clinical cases, images in rheumatology, letters to the editor and clinical teaching (e.g. guidelines and clinical protocols).
Published since 1973, Acta Reumatológica Portuguesa is the official scientific publication of the Portuguese Society of Rheumatology, a non-profit organization that promotes the knowledge and investigation of rheumatic diseases and the development of Rheumatology.
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