Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia.

IF 2 Q3 RESPIRATORY SYSTEM Pulmonary Medicine Pub Date : 2020-09-15 eCollection Date: 2020-01-01 DOI:10.1155/2020/4897038

Vilen Molotov-Luchanskiy, Altynbek Nukhuly, Larissa Muravlyova, Ryszhan Bakirova, Aruna Kossybayeva, Dmitry Klyuyev, Ludmila Demidchik, Irina Beinikova

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Abstract

Materials and methods: 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia. The third group (III), the comparison group, consisted of 14 CAP patients with chronic obstructive pulmonary disease (COPD). The control group consisted of 19 volunteers.

Results: Statistically significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. In the group of patients with moderate severity and severe pneumonia, also in CAP patients with COPD, the level of CD exceeded the control group. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups.

Conclusion: Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease.

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社区获得性肺炎患者中性粒细胞氧化修饰蛋白和中性粒细胞胞外陷阱。

材料与方法:51例CAP患者根据病理过程的严重程度分为两组。第一组(I)包括32例中度肺炎患者。第二组(II) 19例重症肺炎患者。第三组(III)为对照组，14例CAP合并慢性阻塞性肺疾病(COPD)患者。对照组由19名志愿者组成。结果:与对照组相比，各研究组患者的羰基衍生物(CD)水平均有统计学意义的升高。在中、重度肺炎患者组以及CAP合并COPD患者中，CD水平均超过对照组。两组患者血液中性粒细胞中高级氧化蛋白产物(AOPP)和髓过氧化物酶(MPO)水平差异无统计学意义。结论:结果提示中性粒细胞氧化失衡，导致病程恶化。

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