Exploring a role for fatty acid synthase in prostate cancer cell migration.

Q2 Biochemistry, Genetics and Molecular Biology Small GTPases Pub Date : 2021-07-01 Epub Date: 2020-10-12 DOI:10.1080/21541248.2020.1826781
Mario De Piano, Valeria Manuelli, Giorgia Zadra, Massimo Loda, Gordon Muir, Ash Chandra, Jonathan Morris, Mieke Van Hemelrijck, Claire M Wells
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引用次数: 6

Abstract

Fatty acid synthase (FASN) is commonly overexpressed in prostate cancer and associated with tumour progression. FASN is responsible for de novo synthesis of the fatty acid palmitate; the building block for protein palmitoylation. A functional role for FASN in regulating cell proliferation is widely accepted. We recently reported that FASN activity can also mediate prostate cancer HGF-mediated cell motility. Moreover, we found that modulation of FASN expression specifically impacts on the palmitoylation of RhoU. Findings we will describe here. We now report that loss of FASN expression also impairs HGF-mediated cell dissociation responses. Taken together our results provide compelling evidence that FASN activity directly promotes cell migration and supports FASN as a potential therapeutic target in metastatic prostate cancer.

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探讨脂肪酸合酶在前列腺癌细胞迁移中的作用。
脂肪酸合成酶(FASN)在前列腺癌中普遍过表达,并与肿瘤进展相关。FASN负责棕榈酸脂肪酸的从头合成;蛋白质棕榈酰化的组成部分。FASN在调节细胞增殖中的功能作用已被广泛接受。我们最近报道了FASN活性也可以介导前列腺癌hgf介导的细胞运动。此外,我们发现FASN表达的调节特异性地影响RhoU的棕榈酰化。我们将在这里描述这些发现。我们现在报道FASN表达的缺失也会损害hgf介导的细胞解离反应。综上所述,我们的研究结果提供了令人信服的证据,证明FASN活性直接促进细胞迁移,并支持FASN作为转移性前列腺癌的潜在治疗靶点。
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来源期刊
Small GTPases
Small GTPases Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.10
自引率
0.00%
发文量
6
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