A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans.

IF 2.4 Q1 PEDIATRICS Molecular and cellular pediatrics Pub Date : 2020-10-14 DOI:10.1186/s40348-020-00106-4
Julia Körholz, Nicole Richter, Jochen Schäfer, Catharina Schuetz, Joachim Roesler
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引用次数: 1

Abstract

Background: Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing.

Case presentation: We describe a 51-year-old male with dominant partial interferon-gamma-receptor-1 (IFNγR1)-deficiency and recurrent Herpes simplex 2 meningoencephalitis as well as other viral reactivations since childhood.

Conclusions: This case further confirms an enhanced risk for viral disease in IFNγR-deficient patients and a role of interferon gamma for human antiviral defense.

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一例复发性单纯疱疹2型脑炎、VZV再激活和显性部分干扰素- γ受体-1缺乏支持干扰素γ与人类抗病毒防御的相关性。
背景:与分枝杆菌感染不同,干扰素γ受体(IFNγR)缺乏患者中异常病毒感染的报道很少。因此,关于这些患者对病毒感染易感性增加的讨论正在进行中。病例介绍:我们描述了一位51岁男性,患有显性部分干扰素- γ受体-1 (IFNγR1)缺乏和复发性单纯疱疹2型脑膜脑炎,以及自童年以来的其他病毒再激活。结论:该病例进一步证实了ifn γ r缺陷患者发生病毒性疾病的风险增加以及干扰素γ在人类抗病毒防御中的作用。
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