A comparative study to evaluate oral iron and intravenous iron sucrose for treatment of anemia in pregnancy in a poor socioeconomic region of Northeast India.

Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-07-24 eCollection Date: 2020-07-01 DOI:10.4103/tcmj.tcmj_99_19
Maureen P Tigga, Amulya P Debbarma
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Abstract

Objective: The prevalence of anemia during pregnancy is as high as 80% in some sections of the Indian population. Iron therapy in different forms has been found to alleviate anemia and yield good fetomaternal outcome. This study aims to evaluate the efficacy of intravenous iron sucrose (IVIS) versus oral iron in treating anemia among the antenatal mothers attending a tertiary care center of Northeast India.

Materials and methods: One hundred women between 18 and 28 weeks of gestation with diagnosed iron-deficiency anemia and hemoglobin (Hb) of 7-10.9 g/dL were enrolled to be administered either oral ferrous sulfate 200 mg twice daily or requisite dose of IVIS 100 mg in 100 ml normal saline on alternate days. Hb and hematocrit were measured at the time of enrollment, 4th week, and 8th week of therapy. Acceptability of both the drugs based on like and dislike after interviewing the study participants was recorded. Adverse drug reactions, gestational age at delivery, and neonatal birth weight were also noted in both the groups. The results were analyzed by Student's t-test and Chi-square test.

Results: Hb and hematocrit values were found to be increased in both the groups at 4th and 8th weeks. When both the groups were compared, the rise in the values was higher in the iron sucrose group (at 4th week P = 0.01 and at 8th week P = 0.00). The number of participants who reached target Hb levels at 4 weeks was 41 (82%) with oral iron and 48 (96%) with iron sucrose. In the iron sucrose group, no adverse effects were observed, suggesting its safety, and the acceptability and newborn birth weight were noted to be higher.

Conclusion: IVIS was found to be more effective than oral iron therapy in treating antenatal anemia with no serious adverse drug reactions.

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一项比较研究,评估在印度东北部社会经济贫困地区口服铁剂和静脉注射蔗糖铁剂治疗妊娠贫血的效果。
目的:在印度的一些人群中,孕期贫血的发病率高达 80%。研究发现,不同形式的铁剂治疗可减轻贫血,并对胎儿和产妇产生良好的影响。本研究旨在评估静脉注射蔗糖铁(IVIS)和口服铁剂治疗印度东北部一家三级医疗中心的产前母亲贫血的疗效:100 名妊娠 18 至 28 周、确诊缺铁性贫血且血红蛋白(Hb)为 7-10.9 g/dL 的孕产妇被选中,接受口服硫酸亚铁 200 毫克,每日两次,或隔日在 100 毫升生理盐水中加入所需剂量的静脉注射蔗糖铁 100 毫克。在入组时、治疗第 4 周和第 8 周测量血红蛋白和血细胞比容。在对研究参与者进行访谈后,根据喜欢和不喜欢两种药物的程度记录对这两种药物的接受程度。此外,还记录了两组患者的药物不良反应、分娩胎龄和新生儿出生体重。结果通过学生 t 检验和卡方检验进行分析:结果:在第 4 周和第 8 周,两组的血红蛋白和血细胞比容值均有所增加。两组比较发现,蔗糖铁剂组的血红蛋白和血细胞比容值上升幅度更大(第 4 周 P = 0.01,第 8 周 P = 0.00)。口服铁剂组和蔗糖铁剂组分别有 41 人(82%)和 48 人(96%)在 4 周后达到目标血红蛋白水平。在蔗糖铁剂组中,没有观察到不良反应,这表明其安全性,而且可接受性和新生儿出生体重也较高:IVIS在治疗产前贫血方面比口服铁剂更有效,且无严重的药物不良反应。
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