Prognostic Role of Serum Amino Acids in Head and Neck Cancer.

4区 医学 Q3 Medicine Disease Markers Pub Date : 2020-10-01 eCollection Date: 2020-01-01 DOI:10.1155/2020/2291759
Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Stefano Settimi, Jacopo Galli, Gaetano Paludetti, Dario Arzani, Stefania Boccia, Ivo Giovannini, Giovanni Almadori
{"title":"Prognostic Role of Serum Amino Acids in Head and Neck Cancer.","authors":"Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Stefano Settimi, Jacopo Galli, Gaetano Paludetti, Dario Arzani, Stefania Boccia, Ivo Giovannini, Giovanni Almadori","doi":"10.1155/2020/2291759","DOIUrl":null,"url":null,"abstract":"Introduction Serum amino acid (AA) profiles represent a valuable tool in the metabolic assessment of cancer patients; still, information on the AA pattern in head and neck cancer (HNC) patients is insufficient. The aim of the study was to assess whether serum AA levels were associated with the stage of neoplastic disease and prognosis in primary HNC patients. Methods Two hundred and two primary HNC patients were included in the study. Thirty-one AAs and derivatives were measured in serum through an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). The association between AA concentrations and the stage (advanced versus early) of HNC was estimated using a multivariable logistic regression model. A multivariable Cox regression model was used to evaluate the prognostic significance of each AA. Results At the multivariable logistic regression analysis, increased levels of alpha-aminobutyric acid, aminoadipic acid, histidine, proline, and tryptophan were associated with a reduced risk of advanced stage HNC, while high levels of beta-alanine, beta-aminobutyric acid, ethanolamine, glycine, isoleucine, 4-hydroxyproline, and phenylalanine were associated with an increased risk of advanced stage HNC. Furthermore, at multivariate analysis, increased levels of alpha-aminobutyric acid were associated with increased overall survival (OS), while high levels of arginine, ethanolamine, glycine, histidine, isoleucine, 4-hydroxyproline, leucine, lysine, 3-methylhistidine, phenylalanine, and serine were associated with decreased OS. Conclusions Our study suggests that AA levels are associated with the stage of disease and prognosis in patients with HNC. More study is necessary to evaluate if serum AA levels may be considered a hallmark of HNC and prove to be clinically useful markers of disease status and prognosis in HNC patients.","PeriodicalId":11201,"journal":{"name":"Disease Markers","volume":" ","pages":"2291759"},"PeriodicalIF":0.0000,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2291759","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Disease Markers","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2020/2291759","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 15

Abstract

Introduction Serum amino acid (AA) profiles represent a valuable tool in the metabolic assessment of cancer patients; still, information on the AA pattern in head and neck cancer (HNC) patients is insufficient. The aim of the study was to assess whether serum AA levels were associated with the stage of neoplastic disease and prognosis in primary HNC patients. Methods Two hundred and two primary HNC patients were included in the study. Thirty-one AAs and derivatives were measured in serum through an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). The association between AA concentrations and the stage (advanced versus early) of HNC was estimated using a multivariable logistic regression model. A multivariable Cox regression model was used to evaluate the prognostic significance of each AA. Results At the multivariable logistic regression analysis, increased levels of alpha-aminobutyric acid, aminoadipic acid, histidine, proline, and tryptophan were associated with a reduced risk of advanced stage HNC, while high levels of beta-alanine, beta-aminobutyric acid, ethanolamine, glycine, isoleucine, 4-hydroxyproline, and phenylalanine were associated with an increased risk of advanced stage HNC. Furthermore, at multivariate analysis, increased levels of alpha-aminobutyric acid were associated with increased overall survival (OS), while high levels of arginine, ethanolamine, glycine, histidine, isoleucine, 4-hydroxyproline, leucine, lysine, 3-methylhistidine, phenylalanine, and serine were associated with decreased OS. Conclusions Our study suggests that AA levels are associated with the stage of disease and prognosis in patients with HNC. More study is necessary to evaluate if serum AA levels may be considered a hallmark of HNC and prove to be clinically useful markers of disease status and prognosis in HNC patients.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
血清氨基酸在头颈癌预后中的作用。
简介:血清氨基酸(AA)谱是癌症患者代谢评估的一个有价值的工具;然而,关于头颈癌(HNC)患者AA模式的信息仍然不足。该研究的目的是评估血清AA水平是否与原发性HNC患者的肿瘤疾病分期和预后相关。方法:222例原发性HNC患者纳入研究。采用超高效液相色谱-质谱法(UPLC-MS)测定血清中31种原子吸收剂及其衍生物的含量。使用多变量logistic回归模型估计AA浓度与HNC分期(晚期与早期)之间的关系。采用多变量Cox回归模型评价各AA的预后意义。结果:在多变量logistic回归分析中,α -氨基丁酸、氨基己二酸、组氨酸、脯氨酸和色氨酸水平升高与晚期HNC风险降低相关,而β -丙氨酸、β -氨基丁酸、乙醇胺、甘氨酸、异亮氨酸、4-羟基脯氨酸和苯丙氨酸水平升高与晚期HNC风险增加相关。此外,在多变量分析中,α -氨基丁酸水平升高与总生存期(OS)增加有关,而精氨酸、乙醇胺、甘氨酸、组氨酸、异亮氨酸、4-羟脯氨酸、亮氨酸、赖氨酸、3-甲基组氨酸、苯丙氨酸和丝氨酸水平升高与总生存期(OS)降低有关。结论:我们的研究提示AA水平与HNC患者的疾病分期和预后相关。需要更多的研究来评估血清AA水平是否可以被认为是HNC的标志,并证明是HNC患者疾病状态和预后的临床有用标记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Disease Markers
Disease Markers 医学-病理学
自引率
0.00%
发文量
792
审稿时长
6-12 weeks
期刊介绍: Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as their application in the prognosis, diagnosis and treatment of diseases.
期刊最新文献
Impact of rs599839 Polymorphism on Coronary Artery Disease Risk in Saudi Diabetic Patients. Corrigendum to "Fluvastatin Upregulates the α 1C Subunit of CaV1.2 Channel Expression in Vascular Smooth Muscle Cells via RhoA and ERK/p38 MAPK Pathways". JAK2 as Predictor of Therapeutic Response in Patients with Chronic Myeloid Leukemia Treated with Imatinib Significance of Estrogen/Progesterone Receptor Expression in Metaplastic Breast Carcinoma Determination of Tumor Marker Screening for Lung Cancer Using ROC Curves
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1