Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder.

IF 1.7 4区医学 Q4 NEUROSCIENCES International Journal of Neuroscience Pub Date : 2022-08-01 Epub Date: 2020-10-29 DOI:10.1080/00207454.2020.1841187

Ayhan Bilgiç, Sedat Abuşoğlu, Çağla Sadıç Çelikkol, Mehmet Burhan Oflaz, Ömer Faruk Akça, Abdullah Sivrikaya, Tamer Baysal, Ali Ünlü

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引用次数: 7

Abstract

Aim: There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD.

Materials and methods: A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system.

Results: Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower.

Conclusions: These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.

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自闭症谱系障碍幼儿和学龄前儿童犬尿氨酸途径代谢物水平的改变。

目的:关于犬尿氨酸途径代谢物在自闭症谱系障碍(ASD)中的潜在作用的报道越来越多。幼儿期是ASD发病的一个非常关键的时期，以前的研究报道犬尿氨酸代谢存在年龄依赖性改变。然而，没有研究专门检查非常年幼的ASD儿童的犬尿氨酸代谢物。本研究旨在探讨幼儿和学龄前ASD患儿犬尿氨酸途径代谢物水平、犬尿氨酸途径酶活性及神经保护指数(犬尿氨酸/3-羟基犬尿氨酸比值)。材料与方法:本研究共纳入68例年龄在18 ~ 60月龄的ASD患儿和44例健康对照。采用液相色谱-质谱/质谱联用系统测定血清犬尿氨酸途径代谢物水平。结果:ASD组血清3-羟基犬尿氨酸和犬尿酸浓度显著高于对照组，3-羟基苯甲酸浓度显著低于对照组。结论:这些发现提示犬尿氨酸通路可能在儿童早期ASD发病过程中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Neuroscience 医学-神经科学

CiteScore

5.10

自引率

0.00%

发文量

132

审稿时长

2 months

期刊介绍： The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.