Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research.

IF 1.8 4区化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2020-10-23 DOI:10.1080/15685551.2020.1837442

Yazhen Wang, Zhen Shi, Yu Sun, Xueying Wu, Shuang Li, Shaobo Dong, Tianyu Lan

引用次数: 7

Abstract

Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe₃O₄-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe₃O₄ and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe₃O₄-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe₃O₄-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.

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两亲性磁性聚乙烯醇靶向药物载体的制备及给药研究。

目前，磁性材料在药物载体领域具有很大的发展潜力。本文以Fe3O4和PVA为原料，用硫酰肼-亚氨基丙基三乙氧基硅烷(TIPTS)制备了两亲性磁靶向药物载体Fe3O4-PVA@SH。研究了Fe3O4-PVA@SH对阿司匹林的负载能力和负载药物的释放动力学。所得Fe3O4-PVA@SH在模拟人体体液环境(pH 7.2)中表现出优异的药物释放性能。由于磁性靶向药物载体易于获得，具有良好的生物相容性和药物释放特性。本工作的开展，对制备两亲性磁性靶向药物载体在药物递送等领域具有重要意义。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications