Thirteen-month duration of immunity of an oral canine vaccine against challenge with Bordetella bronchiseptica.

IF 1.3 Q2 VETERINARY SCIENCES Veterinary Record Open Pub Date : 2020-10-16 eCollection Date: 2020-01-01 DOI:10.1136/vetreco-2020-000423
Maya Scott-Garrard, Xinshuo Wang, Yu-Wei Chiang, Frederic David
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引用次数: 3

Abstract

Background: Very few studies have evaluated the duration of immunity of Bordetella bronchiseptica vaccines in dogs, and to date, no studies have been published on the duration of immunity of oral canine Bordetella bronchiseptica vaccines. This study was designed to determine the effectiveness of a single dose of an oral B bronchiseptica vaccine in dogs when challenged 13 months after vaccination.

Methods: Two groups of approximately eight-week-old beagles were vaccinated once with 1 ml of placebo vaccine (oral, n=17) or 1 ml of Recombitek Oral Bordetella (oral, n=17). Thirteen months after vaccination, both groups were challenged with virulent B bronchiseptica via aerosolisation.

Results: Thirteen of 17 dogs in the placebo group (76.5 per cent) and no dogs in the Recombitek Oral Bordetella vaccine group (0.0 per cent) developed spontaneous cough of two or more consecutive days (disease case definition). Dogs in the Recombitek Oral Bordetella group had a significantly lower prevalence of disease with prevented fraction of 1 (100 per cent prevention). In addition, the number of days coughing, duration of cough and prevalence of tracheal and nasal shedding were significantly lower for dogs vaccinated with Recombitek Oral Bordetella.

Conclusions: The study demonstrated that vaccination with Recombitek Oral Bordetella is effective in preventing disease and reducing shedding 13 months after vaccination when compared with dogs vaccinated with a placebo.

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犬口服疫苗对支气管脓毒杆菌攻击的13个月免疫期。
背景:很少有研究评估狗对支气管脓毒杆菌疫苗的免疫持续时间,到目前为止,还没有关于口服犬支气管脓毒杆菌疫苗免疫持续时间的研究发表。本研究旨在确定在接种疫苗13个月后,单剂量口服B支菌病疫苗对犬的有效性。方法:两组约8周龄的小猎犬分别接种1 ml安慰剂疫苗(口服,n=17)或1 ml Recombitek oral Bordetella疫苗(口服,n=17)。接种疫苗13个月后,两组均通过雾化方式感染毒力强的结核分枝杆菌。结果:安慰剂组17只狗中有13只(76.5%),而Recombitek口服博德泰拉疫苗组没有狗(0.0%)出现连续两天或更长时间的自发性咳嗽(疾病病例定义)。Recombitek口腔博德泰拉组的狗的患病率显著降低,预防比例为1(100%预防)。此外,接种Recombitek Oral Bordetella疫苗的狗的咳嗽天数、咳嗽持续时间以及气管和鼻腔脱落的发生率均显著降低。结论:该研究表明,与接种安慰剂的狗相比,接种Recombitek Oral Bordetella疫苗在接种后13个月有效预防疾病并减少脱落。
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来源期刊
Veterinary Record Open
Veterinary Record Open VETERINARY SCIENCES-
CiteScore
3.00
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: Veterinary Record Open is a journal dedicated to publishing specialist veterinary research across a range of topic areas including those of a more niche and specialist nature to that considered in the weekly Vet Record. Research from all disciplines of veterinary interest will be considered. It is an Open Access journal of the British Veterinary Association.
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