Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications.

4区医学 Q4 Medicine BMC Medical Genetics Pub Date : 2020-11-23 DOI:10.1186/s12881-020-01169-w

Danyal Imani, Mohammad Masoud Eslami, Gholamreza Anani-Sarab, Mansur Aliyu, Bahman Razi, Ramazan Rezaei

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Abstract

Background: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.

Methods: An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran's Q and the I² statistics were used to evaluate the degree of heterogeneity between studies.

Results: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans.

Conclusions: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

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白细胞介素-4 基因多态性（C33T）与哮喘风险：基于 24 篇出版物的荟萃分析。

背景：以前的研究评估了IL-4 C33T多态性与支气管哮喘风险的关联，但未能建立一致的确凿关联。在本荟萃分析中，我们打算在已发表的文献较多的情况下，对两者之间的关系做出更可靠的估计：方法：我们在 Web of Science、Scopus 和 PubMed 数据库中进行了详尽的检索，以确定 2020 年 9 月之前的所有相关文献，最终分析纳入了 24 篇文献（28 项研究）、6587 例病例和 8408 例对照。多态性与哮喘风险之间的关系以奇数比（OR）和95%置信区间（CI）来衡量。此外，还使用 Cochran's Q 和 I2 统计量来评估研究之间的异质性程度：结果：在总体研究人群中，所有基因型模型均发现了显著的正相关性，这表明 IL-4 C33T 多态性是哮喘发病机制中的一个潜在风险因素。在按年龄进行的亚组分析中，在等位基因模型中，IL-4 C33T 多态性与不同年龄组的哮喘风险之间存在显著关联，这突出表明在所有三个年龄组中，T 等位基因对哮喘风险具有易感作用。此外，按洲进行的亚组分析结果也不尽相同。因此，IL-4 C33T 多态性是欧洲人（除杂合子比较外的所有模型）、美国人（除隐性和同源杂合子比较外的所有模型）和亚洲人（仅隐性和等位基因模型）的风险因素。最后，种族特异性分析显示，白种人（除杂合子比较外的所有基因型模型）的IL-4 C33T多态性与哮喘风险之间存在显著关联，而非裔美国人的这种关联并不显著：本研究表明，IL-4 C33T 多态性可能是不同种族和年龄组的哮喘风险因素。

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BMC Medical Genetics 医学-遗传学

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0.00%

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审稿时长

12 months

期刊介绍： BMC Medical Genetics is an open access journal publishing original peer-reviewed research articles in the effects of genetic variation in individuals, families and among populations in relation to human health and disease. Note: BMC Medical Genetics is now closed. This journal has merged with BMC Medical Genomics, a broad-scope, open access community journal for all medical genetics and genomics research.