{"title":"Association of Maternal Dietary Components During Pregnancy and/or Lactation with Insulin-Dependent Diabetes Mellitus.","authors":"Shadi Salek, Mahin Hashemipour, Awat Feizi, Silva Hovsepian, Roya Kelishadi","doi":"10.5812/ijem.93076","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Considering the increasing trend in the incidence of type 1 diabetes mellitus (T1DM), the identification of its environmental determinants, especially those related to the prenatal and lactation period, might ultimately result in primary prevention of the disease. We aimed to review the evidence of the association between mothers' dietary components during pregnancy and/or lactation with T1DM.</p><p><strong>Evidence acquisition: </strong>An electronic and comprehensive literature search was performed until August 2019 in the international databases, including Web of Science (ISI), PubMed, and Scopus, using the following keywords: type 1 diabetes mellitus, autoimmunity, mother, maternal, diet and lactation in different combinations. Papers related to the objectives of the study were selected.</p><p><strong>Results: </strong>Based on our review, the maternal consumption of meat, especially processed meat, was associated with increased risk of T1DM, whereas the maternal use of vegetables, potato, low-fat margarine, and berries showed protective effects against the development of T1DM in offspring. There was no significant association between the use of multivitamins and mineral supplements with T1DM, according to the available data. The results of the reviewed studies regarding the association between the maternal use of vitamin D, fatty acids, and coffee during pregnancy with T1DM were not consistent and conclusive.</p><p><strong>Conclusions: </strong>Findings of this review indicate that the maternal consumption of some foods is associated with increased or decreased risk of T1DM. However, for some foods or dietary components, including coffee, vitamin D, and fatty acids, the results are not conclusive. We conclude that although maternal diet could influence the development of insulin autoantibodies (IA) and T1DM in offspring, there is no sufficient evidence for most nutrients, and available data are controversial, which should be dealt with in future cohort or interventional studies.</p>","PeriodicalId":13969,"journal":{"name":"International Journal of Endocrinology and Metabolism","volume":"18 3","pages":"e93076"},"PeriodicalIF":2.1000,"publicationDate":"2020-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/dc/ijem-18-3-93076.PMC7695223.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Endocrinology and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5812/ijem.93076","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/7/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 1
Abstract
Context: Considering the increasing trend in the incidence of type 1 diabetes mellitus (T1DM), the identification of its environmental determinants, especially those related to the prenatal and lactation period, might ultimately result in primary prevention of the disease. We aimed to review the evidence of the association between mothers' dietary components during pregnancy and/or lactation with T1DM.
Evidence acquisition: An electronic and comprehensive literature search was performed until August 2019 in the international databases, including Web of Science (ISI), PubMed, and Scopus, using the following keywords: type 1 diabetes mellitus, autoimmunity, mother, maternal, diet and lactation in different combinations. Papers related to the objectives of the study were selected.
Results: Based on our review, the maternal consumption of meat, especially processed meat, was associated with increased risk of T1DM, whereas the maternal use of vegetables, potato, low-fat margarine, and berries showed protective effects against the development of T1DM in offspring. There was no significant association between the use of multivitamins and mineral supplements with T1DM, according to the available data. The results of the reviewed studies regarding the association between the maternal use of vitamin D, fatty acids, and coffee during pregnancy with T1DM were not consistent and conclusive.
Conclusions: Findings of this review indicate that the maternal consumption of some foods is associated with increased or decreased risk of T1DM. However, for some foods or dietary components, including coffee, vitamin D, and fatty acids, the results are not conclusive. We conclude that although maternal diet could influence the development of insulin autoantibodies (IA) and T1DM in offspring, there is no sufficient evidence for most nutrients, and available data are controversial, which should be dealt with in future cohort or interventional studies.
背景:考虑到1型糖尿病(T1DM)发病率的上升趋势,确定其环境决定因素,特别是与产前和哺乳期有关的环境决定因素,可能最终导致该疾病的一级预防。我们的目的是回顾孕期和/或哺乳期母亲饮食成分与T1DM之间关系的证据。证据获取:截至2019年8月,在包括Web of Science (ISI)、PubMed和Scopus在内的国际数据库中进行了电子和全面的文献检索,使用以下关键词:1型糖尿病、自身免疫、母亲、母体、不同组合的饮食和哺乳。选择与研究目标相关的论文。结果:根据我们的综述,母亲食用肉类,特别是加工肉类,与T1DM的风险增加有关,而母亲食用蔬菜、土豆、低脂人造黄油和浆果对后代T1DM的发展有保护作用。根据现有的数据,复合维生素和矿物质补充剂的使用与T1DM之间没有显著的联系。关于孕妇在妊娠期间服用维生素D、脂肪酸和咖啡与T1DM之间关系的研究结果并不一致,也没有结论性。结论:本综述的发现表明,母亲食用某些食物与T1DM风险的增加或降低有关。然而,对于一些食物或饮食成分,包括咖啡、维生素D和脂肪酸,结果并不确定。我们的结论是,尽管母亲的饮食可能会影响后代胰岛素自身抗体(IA)和T1DM的发展,但大多数营养物质没有足够的证据,现有的数据是有争议的,这应该在未来的队列或干预研究中进行处理。
期刊介绍:
The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.