{"title":"Contribution of long noncoding RNA <i>HOTAIR</i> variants to preeclampsia susceptibility in Iranian women.","authors":"Sahra Esmkhani, Hossein Sadeghi, Majid Ghasemian, Reihaneh Pirjani, Mona Amin-Beidokhti, Milad Gholami, Fakhrolmolouk Yassaee, Reza Mirfakhraie","doi":"10.1080/10641955.2020.1855192","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objective</b>: To investigate the possible association of lncRNA <i>HOTAIR</i> rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. <b>Method</b>: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. <b>Results</b>: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, <i>P</i> < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, <i>P</i> < 0.0001; respectively). <b>Conclusion</b>: This study confirmed the association of <i>HOTAIR</i> rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"29-35"},"PeriodicalIF":1.5000,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1855192","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hypertension in Pregnancy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10641955.2020.1855192","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/12/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 3
Abstract
Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.
期刊介绍：
Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.
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