Initial Validation of Proton Dose Calculations on SPR Images from DECT in Treatment Planning System.

IF 2.1 Q3 ONCOLOGY International Journal of Particle Therapy Pub Date : 2020-11-23 eCollection Date: 2020-01-01 DOI:10.14338/IJPT-XX-000XX.1
Sina Mossahebi, Pouya Sabouri, Haijian Chen, Michelle Mundis, Matthew O'Neil, Paul Maggi, Jerimy C Polf
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Abstract

Purpose: To investigate and quantify the potential benefits associated with the use of stopping-power-ratio (SPR) images created from dual-energy computed tomography (DECT) images for proton dose calculation in a clinical proton treatment planning system (TPS).

Materials and methods: The DECT and single-energy computed tomography (SECT) scans obtained for 26 plastic tissue surrogate plugs were placed individually in a tissue-equivalent plastic phantom. Relative-electron density (ρe) and effective atomic number (Z eff) images were reconstructed from the DECT scans and used to create an SPR image set for each plug. Next, the SPR for each plug was measured in a clinical proton beam for comparison of the calculated values in the SPR images. The SPR images and SECTs were then imported into a clinical TPS, and treatment plans were developed consisting of a single field delivering a 10 × 10 × 10-cm3 spread-out Bragg peak to a clinical target volume that contained the plugs. To verify the accuracy of the TPS dose calculated from the SPR images and SECTs, treatment plans were delivered to the phantom containing each plug, and comparisons of point-dose measurements and 2-dimensional γ-analysis were performed.

Results: For all 26 plugs considered in this study, SPR values for each plug from the SPR images were within 2% agreement with measurements. Additionally, treatment plans developed with the SPR images agreed with the measured point dose to within 2%, whereas a 3% agreement was observed for SECT-based plans. γ-Index pass rates were > 90% for all SECT plans and > 97% for all SPR image-based plans.

Conclusion: Treatment plans created in a TPS with SPR images obtained from DECT scans are accurate to within guidelines set for validation of clinical treatment plans at our center. The calculated doses from the SPR image-based treatment plans showed better agreement to measured doses than identical plans created with standard SECT scans.

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在治疗计划系统中利用 DECT 的 SPR 图像计算质子剂量的初步验证。
目的:研究并量化在临床质子治疗计划系统(TPS)中使用双能计算机断层扫描(DECT)图像创建的停止功率比(SPR)图像进行质子剂量计算的潜在好处:将 26 个塑料组织替代插头的双能计算机断层扫描(DECT)和单能计算机断层扫描(SECT)扫描图像分别放置在一个组织等效塑料模型中。通过 DECT 扫描重建相对电子密度 (ρe)和有效原子序数 (Z eff) 图像,并利用这些图像为每个塞子创建 SPR 图像集。然后,在临床质子束中测量每个塞子的 SPR,以便与 SPR 图像中的计算值进行比较。然后将 SPR 图像和 SECTs 导入临床 TPS,并制定治疗计划,其中包括向包含塞子的临床靶体积提供 10 × 10 × 10 立方厘米扩散布拉格峰的单场。为了验证根据 SPR 图像和 SECT 计算出的 TPS 剂量的准确性,对包含每个塞子的模型实施了治疗计划,并进行了点剂量测量和二维 γ 分析的比较:对于本研究中考虑的所有 26 个插头,SPR 图像中每个插头的 SPR 值与测量值的一致性在 2% 以内。此外,根据 SPR 图像制定的治疗计划与测量点剂量的一致性在 2% 以内,而基于 SECT 的计划的一致性为 3%。所有 SECT 计划的 γ 指数合格率均大于 90%,所有基于 SPR 图像的计划的 γ 指数合格率均大于 97%:结论:利用从 DECT 扫描中获得的 SPR 图像在 TPS 中创建的治疗计划准确度符合本中心为验证临床治疗计划而制定的准则。与使用标准 SECT 扫描创建的相同计划相比,基于 SPR 图像的治疗计划的计算剂量与测量剂量的一致性更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Particle Therapy
International Journal of Particle Therapy Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.70
自引率
5.90%
发文量
23
审稿时长
20 weeks
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