A t(8;14)(q24.1;q32) in Plasma Cell Myeloma: A Case Report and Literature Review.

Abstract

Objectives: We report a 74-year-old male whose bone marrow morphology, flow cytometry, MRI and serum electrophoresis showed evidence of plasma cell myeloma. Chromosome analysis of the bone marrow showed an abnormal karyotype, described as 51~53,XY,+3,+5,t(8;14)(q24 .1;q32),+9,+11,+15,+19,+21[cp6]/46,XY[14]. The t(8;14)(q24.1;q32) is mainly seen in Burkitt lymphoma but it can also be seen in plasma cell myeloma usually with the context of a complex karyotype. Based on the Mitelman database the involvement of C-MYC is usually seen in late tumor progression in plasma cell myeloma as a secondary rearrangement, usually during clonal evolution and divergence and is associated with a significantly decreased survival. Our case pinpoints the involvement of MYC abnormalities in plasma cell myeloma as well as the importance of cytogenetics as a tool to manage and monitor plasma cell myeloma cases.