Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review.

IF 2.4 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Oral & Facial Pain and Headache Pub Date : 2020-09-01 DOI:10.11607/ofph.2641

Flávia Fonseca Carvalho Soares, Rodrigo Lorenzi Poluha, Giancarlo De la Torre Canales, Yuri Martins Costa, Gustavo G Nascimento, Paulo César Rodrigues Conti, Leonardo Rigoldi Bonjardim

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引用次数: 6

Abstract

Aims: To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders.

Methods: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms.

Results: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways.

Conclusion: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets.

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遗传多态性对口面部疼痛敏感性的影响:系统综述。

目的:系统地回顾文献，以评估遗传多态性是否影响健康个体和慢性口腔面部疼痛疾病患者的口腔面部疼痛敏感性。方法:在健康个体和/或慢性口腔面部疼痛疾病患者中进行电子检索，以确定调查遗传多态性与口腔面部疼痛敏感性之间关系的观察性研究和临床试验。使用医学主题词和免费术语在PubMed、Embase和Scopus数据库中进行搜索。结果:7项研究符合入选标准:4项研究分析健康受试者，2项研究分析慢性口面部疼痛患者，1项研究分析健康受试者和神经性疼痛患者。结果表明，与机械痛和热痛敏感相关的基因主要与阿片、儿茶酚胺能、炎症和多巴胺能通路有关。结论:与阿片、儿茶酚胺能、炎症和多巴胺能通路相关的遗传多态性与口面部区域对热压力刺激的敏感性有关。因此，遗传因素应该考虑到一个准确的解释口面部疼痛敏感性。这些结果将有助于更好地了解影响口腔面部区域的慢性疼痛的发病机制，从而找到新的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral & Facial Pain and Headache DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

5.10

自引率

4.00%

发文量

期刊介绍： Founded upon sound scientific principles, this journal continues to make important contributions that strongly influence the work of dental and medical professionals involved in treating oral and facial pain, including temporomandibular disorders, and headache. In addition to providing timely scientific research and clinical articles, the journal presents diagnostic techniques and treatment therapies for oral and facial pain, headache, mandibular dysfunction, and occlusion and covers pharmacology, physical therapy, surgery, and other pain-management methods.