Association of Adipose Tissue Distribution With Type 2 Diabetes in Breast Cancer Patients.

IF 1.8 Q3 ONCOLOGY Breast Cancer : Basic and Clinical Research Pub Date : 2020-11-23 eCollection Date: 2020-01-01 DOI:10.1177/1178223420972369
Jia Qi, Hui Hu, Lusine Yaghjyan, Lejun An, Harris A Kalim, Erinn O Cooke, Ting-Yuan David Cheng
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引用次数: 2

Abstract

Purpose: We examined the association of adipose tissue distribution with type 2 diabetes (T2D) in breast cancer patients.

Methods: Participants (N = 238) diagnosed with breast cancer at 20-75 years old who received breast cancer treatment at a major hospital from January 1, 2012, to December 31, 2017, with at least one completed and identifiable abdominal or pelvic computed tomography (CT) scan and data regarding race and ethnicity were included. Thirty-two breast cancer patients were identified as T2D patients after their breast cancer diagnoses. The adipose tissue distribution (visceral fat area [VFA], subcutaneous fat area [SFA], and the ratio of VFA to SFA [VFA/SFA]) was quantified on CT images of the third lumbar vertebra. T2D status was retrieved from patients' electronic medical records. The association of adipose tissue distribution with T2D in women with breast cancer was examined using multivariable logistic regression.

Results: Participants with T2D had significantly smaller SFA compared to those without T2D (odds ratio [OR] = 0.88, 95% confidence interval [95% CI] = 0.81-0.96, per 10 cm2 SFA). A positive association of VFA/SFA ratio with T2D was observed (OR = 19.57, 95% CI = 3.26-117.42, per unit VFA/SFA), although the estimate was imprecise.

Conclusions: The amount of subcutaneous adipose tissue was inversely associated with T2D, and the ratio of the amount of visceral adipose tissue to the amount of subcutaneous adipose tissue was positively associated with T2D in breast cancer patients.

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乳腺癌患者脂肪组织分布与2型糖尿病的关系
目的:研究乳腺癌患者脂肪组织分布与2型糖尿病(T2D)的关系。方法:纳入2012年1月1日至2017年12月31日期间在某大医院接受乳腺癌治疗的20-75岁乳腺癌患者(N = 238),至少进行一次完整且可识别的腹部或骨盆计算机断层扫描(CT),并纳入种族和民族相关数据。32例乳腺癌患者在乳腺癌诊断后被确定为T2D患者。在第三腰椎CT图像上量化脂肪组织分布(内脏脂肪区[VFA]、皮下脂肪区[SFA]及VFA/SFA比值)。从患者的电子病历中检索T2D状态。采用多变量logistic回归分析了乳腺癌患者脂肪组织分布与T2D的关系。结果:T2D患者的SFA显著小于无T2D患者(比值比[OR] = 0.88, 95%可信区间[95% CI] = 0.81-0.96,每10 cm2 SFA)。观察到VFA/SFA比值与T2D呈正相关(OR = 19.57, 95% CI = 3.26-117.42,单位VFA/SFA),尽管估计不精确。结论:乳腺癌患者皮下脂肪组织数量与T2D呈负相关,内脏脂肪组织数量与皮下脂肪组织数量之比与T2D呈正相关。
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来源期刊
CiteScore
5.10
自引率
3.40%
发文量
22
审稿时长
8 weeks
期刊介绍: Breast Cancer: Basic and Clinical Research is an international, open access, peer-reviewed, journal which considers manuscripts on all areas of breast cancer research and treatment. We welcome original research, short notes, case studies and review articles related to breast cancer-related research. Specific areas of interest include, but are not limited to, breast cancer sub types, pathobiology, metastasis, genetics and epigenetics, mammary gland biology, breast cancer models, prevention, detection, therapy and clinical interventions, and epidemiology and population genetics.
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