[Bacteremia pathogens in the University Hospital Olomouc].

Q3 Medicine Klinicka mikrobiologie a infekcni lekarstvi Pub Date : 2020-03-01
Miroslava Htoutou Sedlaková, Kateřina Fišerová, Milan Kolář
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Abstract

Objectives: To provide an overview of the most common bacterial species isolated from blood cultures in the University Hospital Olomouc in the years 2015-2019 and their antibiotic resistance patterns.

Material and methods: The data were obtained from the laboratory information management system ENVIS LIMS. The results were analyzed retrospectively for the period from January 1, 2015 to December 31, 2019. Among positive blood cultures, the prevalence of bacterial species was assessed and the most frequent species were evaluated for resistance to selected antibiotics. Each sample was processed using standard microbiology methods with the MALDI-TOF MS system. Susceptibility to antibiotics was tested with the microdilution method according to the EUCAST recommendations.

Results: Over the study period, a total of 3 400 isolates from blood cultures were included. Coagulase-negative staphylococci were the most prevalent (37 %), followed by Escherichia coli (16 %), Klebsiella pneumoniae (9 %), Staphylococcus aureus (7 %), Streptococcus spp. (5 %), Pseudomonas aeruginosa (4 %), Enterobacter cloacae (2 %), Enterococcus faecalis (2 %) and Enterococcus faecium (2 %). Resistance of E. coli to 3rd generation cephalosporins, piperacillin/tazobactam, gentamicin and fluoroquinolones ranged from 7 % to 33 %. A high percentage of Klebsiella pneumoniae strains (33 %-65 %) was resistant to the above antibiotics. The prevalence of methicillin-resistant Staphylococcus aureus reached 3-7 %. Pseudomonas aeruginosa exhibited resistance to piperacillin/tazobactam, ceftazidime, cefepime, meropenem, ciprofloxacin and gentamicin ranging from 3 % to 46 %.

Conclusion: Knowing the prevalence of bacterial species from blood cultures and their antimicrobial resistance patterns is important for empirical antibiotic therapy in case of an existing infection. It is advisable to conduct such epidemiological studies as part of antibiotic stewardship.

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[奥洛穆茨大学医院菌血症病原体]。
目的:概述奥洛穆茨大学医院2015-2019年从血液培养中分离出的最常见细菌种类及其抗生素耐药性模式。材料和方法:数据来源于实验室信息管理系统ENVIS LIMS。对2015年1月1日至2019年12月31日的结果进行回顾性分析。在阳性血培养中,评估了细菌种类的流行情况,并评估了最常见的物种对选定抗生素的耐药性。每个样品采用标准微生物学方法,用MALDI-TOF质谱系统进行处理。采用微量稀释法,按照EUCAST建议进行抗生素药敏试验。结果:研究期间共检获血培养分离株3 400株。以凝固酶阴性葡萄球菌最多(37%),其次是大肠杆菌(16%)、肺炎克雷伯菌(9%)、金黄色葡萄球菌(7%)、链球菌(5%)、铜绿假单胞菌(4%)、阴沟肠杆菌(2%)、粪肠球菌(2%)和屎肠球菌(2%)。大肠杆菌对第三代头孢菌素、哌拉西林/他唑巴坦、庆大霉素和氟喹诺酮类药物的耐药率为7%至33%。肺炎克雷伯菌菌株对上述抗生素耐药的比例较高(33% ~ 65%)。耐甲氧西林金黄色葡萄球菌患病率达3- 7%。铜绿假单胞菌对哌拉西林/他唑巴坦、头孢他啶、头孢吡肟、美罗培南、环丙沙星和庆大霉素的耐药率为3%至46%。结论:了解血培养细菌种类的流行情况及其耐药模式对已有感染的经验性抗生素治疗具有重要意义。将此类流行病学研究作为抗生素管理的一部分是可取的。
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Klinicka mikrobiologie a infekcni lekarstvi
Klinicka mikrobiologie a infekcni lekarstvi Medicine-Infectious Diseases
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