Delayed Post-Hypoxic Leukoencephalopathy Caused by Fentanyl Intoxication in a Healthy Woman.

Abstract

Delayed post-hypoxic leukoencephalopathy (DPHL) is a rare disease caused by an anoxic event, such as carbon monoxide (CO) or asphyxial gas poisoning, cardiac arrest, and opiate or benzodiazepine overuse.1-4 At the time of prolonged cerebral hypo-oxygenation, the first manifestation is altered mental status, which is followed by a dramatic recovery. After a few days to weeks, cognitive impairment, gait disorders, parkinsonism, akinetic mutism, and psychosis can appear. We report a patient with DPHL following fentanyl patch intoxication who recovered fully, as confirmed by neuropsychiatric testing.