Ambulatory Blood Pressure Profiles and Correlation with Cardiovascular Risk Factors in a Sample of 390 University Employees in Tanzania.

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE Integrated Blood Pressure Control Pub Date : 2020-12-23 eCollection Date: 2020-01-01 DOI:10.2147/IBPC.S280763
Godfrey Chuwa, Pilly Chillo
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Abstract

Background: Hypertension is a major risk factor for cardiovascular morbidity and mortality. Increasingly, evidence suggests that 24-hour ambulatory blood pressure (BP) monitoring (ABPM) is more accurate than clinic BP in predicting cardiovascular risk. However, this association has not been widely studied in subSaharan Africa, especially in Tanzania.

Aim: To explore the relationship between 24-hour ABPM profiles and cardiovascular risk factors in comparison with clinic BP among Muhimbili University of Health and Allied Sciences (MUHAS) employees.

Methods: A descriptive cross-sectional study was conducted from October 2018 to February 2019. Socio-demographic and cardiovascular risk information was gathered. We used an automated ABPM device to record 24-hour ambulatory BP. Correlation between BP profiles and cardiovascular risk factors was done using Pearson's correlation coefficient, and independent factors for hypertension were determined using logistic regression analysis. P-value of <0.05 was considered statistically significant.

Results: In total, 390 employees participated. Their mean age was 40.5 ± 8.9 years, and 53.6% were men. The mean office systolic and diastolic BP were 126±12 mmHg and 78±13 mmHg, respectively, while the corresponding values for mean 24-hour ABPM were 122±14 and 75±10 mmHg. The prevalence of hypertension was 23.1%. The prevalence of white coat hypertension was 16.2%, while masked hypertension and nocturnal non-dipping were present in 11.5 and 66.7%, respectively. Overall, the mean 24-hour systolic BP showed the strongest correlations with cardiovascular risk factors while mean office systolic BP showed least. Independent associated factors of hypertension were male gender, age ≥40 years, family history of hypertension, central obesity, raised cholesterol and uric acid levels, all p<0.01.

Conclusion: Compared to office BP, ABPM measurements had stronger correlations with cardiovascular risk factors in this population, and therefore likely to reflect true BP. ABPM has revealed high proportion of masked, white coat and nocturnal non-dipping, supporting use of ABPM to detect these clinically important BP profiles.

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坦桑尼亚390名大学员工动态血压特征及其与心血管危险因素的相关性
背景:高血压是心血管疾病发病和死亡的主要危险因素。越来越多的证据表明,24小时动态血压监测(ABPM)在预测心血管风险方面比临床血压更准确。然而,在撒哈拉以南非洲,特别是坦桑尼亚,这种联系尚未得到广泛研究。目的:探讨Muhimbili卫生与联合科学大学(MUHAS)员工24小时血压与心血管危险因素的关系。方法:于2018年10月至2019年2月进行描述性横断面研究。收集社会人口统计学和心血管风险信息。我们使用自动ABPM设备记录24小时动态血压。采用Pearson相关系数分析血压与心血管危险因素的相关性,采用logistic回归分析确定高血压的独立因素。结果的p值:共有390名员工参与。平均年龄40.5±8.9岁,男性53.6%。平均收缩压和舒张压分别为126±12 mmHg和78±13 mmHg,平均24小时ABPM分别为122±14和75±10 mmHg。高血压患病率为23.1%。白大褂高血压患病率为16.2%,隐匿性高血压和夜间不沾高血压患病率分别为11.5%和66.7%。总体而言,平均24小时收缩压与心血管危险因素的相关性最强,而平均办公室收缩压与心血管危险因素的相关性最小。高血压的独立相关因素有男性、年龄≥40岁、高血压家族史、中心性肥胖、胆固醇和尿酸水平升高等。结论:与办公室血压相比,ABPM测量与该人群心血管危险因素的相关性更强,因此可能反映真实的血压。ABPM显示了高比例的蒙面、白大褂和夜间不浸入,支持使用ABPM检测这些临床重要的血压特征。
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来源期刊
Integrated Blood Pressure Control
Integrated Blood Pressure Control PERIPHERAL VASCULAR DISEASE-
CiteScore
4.60
自引率
0.00%
发文量
13
审稿时长
16 weeks
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