Ayurvedic metal nanoparticles could be novel antiviral agents against SARS-CoV-2.

IF 4.1 Q2 NANOSCIENCE & NANOTECHNOLOGY International Nano Letters Pub Date : 2021-01-01 Epub Date: 2021-01-06 DOI:10.1007/s40089-020-00323-9

Prasanta Kumar Sarkar, Chitrangada Das Mukhopadhyay

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Abstract

Purpose of review: The pandemic COVID-19 has affected more than seventy million people globally. The whole world is eagerly waiting for an effective antiviral therapy to combat COVID-19, but it is yet to get. The emergence of COVID-19 makes imperative the need for safe and potent antiviral drugs. Many metal nanoparticles exhibit significant antiviral potential against many viral diseases. The Ayurvedic system of medicine is the treasure of many metal nanoparticulate drugs termed as Bhasma.

Recent findings: Gold, silver, copper, zinc and iron oxide nanoparticles are effective against coronavirus. A possible mechanism of action of the metal nanoparticles against coronavirus is a disruption of outer layers of coronavirus. Swarna Bhasma, Rajata Bhasma, Tamra Bhasma and Yashada Bhasma are recommended for COVID-19 treatment due to the ability to reduce the plasma interleukins, interferons and TNFα levels.

Summary: The Ayurvedic Bhasma preparations are unique metal nanoparticles. These metal nanoparticles are safe, stable in solid state and are having excellent biological activities. Ayurvedic metal nanoparticles, Swarna Bhasma, Rajata Bhasma, Tamra Bhasma and Yashada Bhasma could be proved as novel antiviral agents against SARS-CoV-2 for their anti-inflammatory, immunomodulatory, antiviral and adjuvant activities.

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阿育吠陀金属纳米粒子可作为抗 SARS-CoV-2 的新型抗病毒药物。

审查目的：COVID-19 大流行已影响到全球七千多万人。全世界都在翘首以盼一种有效的抗病毒疗法来对抗 COVID-19，但目前还没有。COVID-19 的出现使得安全有效的抗病毒药物成为当务之急。许多金属纳米粒子对许多病毒性疾病具有显著的抗病毒潜力。阿育吠陀医学体系是许多被称为 Bhasma 的金属纳米颗粒药物的宝库：金、银、铜、锌和氧化铁纳米粒子对冠状病毒有效。金属纳米粒子对冠状病毒的作用机制可能是破坏冠状病毒的外层。由于 Swarna Bhasma、Rajata Bhasma、Tamra Bhasma 和 Yashada Bhasma 能够降低血浆中白细胞介素、干扰素和 TNFα 的水平，因此被推荐用于 COVID-19 的治疗。这些金属纳米颗粒安全、固态稳定，具有出色的生物活性。阿育吠陀金属纳米粒子 Swarna Bhasma、Rajata Bhasma、Tamra Bhasma 和 Yashada Bhasma 具有抗炎、免疫调节、抗病毒和佐剂活性，可被证明是抗 SARS-CoV-2 的新型抗病毒剂。

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来源期刊

International Nano Letters NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

8.30

自引率

2.70%

发文量

期刊介绍： The overall aim of the International Nano Letters is to bring science and applications together on nanoscale and nanostructured materials with emphasis on synthesis, processing, characterization, and applications of materials containing true nanosize dimensions or nanostructures that enable novel/enhanced properties or functions. It is directed at both academic researchers and practicing engineers. International Nano Letters is covering fundamental and applied research in all disciplines of science, engineering and medicine. INL publishes all aspects of nanoscale science and technology dealing with materials synthesis, processing, nanofabrication, nano-polymer, nano-catalyst, nano-particles, nano-probes, spectroscopy, properties, biological systems, nano-structures, theory and computation, nano-electronics, nano-optics, nano-mechanics, nano-devices, nano-detection, nano-biotechnology, nano-medicine, nano-drug delivery, nano-toxicology. All articles should emphasize original results relating to experimental, theoretical, computational, and/or applications of nanomaterials. All contributions will be peer reviewed.