{"title":"Antihyperglycemic and Antidyslipidemic Activities of the <i>Aqueous Salvia hispanica</i> Extract in Diabetic Rat.","authors":"El-Ouady Fadwa, Ayoub Amssayef, Mohamed Eddouks","doi":"10.2174/1871525719666210112154340","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>The study targeted to evaluate the antihyperglycemic activity of Salvia hispanica.</p><p><strong>Background: </strong>Salvia hispanica L. (Lamiaceae) is a medicinal plant with many beneficial properties on human health.</p><p><strong>Objective: </strong>This objective of the study was to investigate the antihyperglycemic effect of the aqueous extract of Salvia hispanica (S. hispanica) seeds and its capacity to improve lipid profile in normal and STZ-induced diabetic rats.</p><p><strong>Material and methods: </strong>The seed aqueous extract of S. hispanica (SHSAE) at a dose of 100 mg/kg was administered orally in normal and diabetic rats. The effect of oral SHSAE treatment on blood glucose and lipid levels during 15 days was assessed in normal and streptozotocin-induced diabetic rats. The oral glucose tolerance test (OGTT) was carried out. The antioxidant activity of SHSAE was also examined.</p><p><strong>Results: </strong>The decrease of glycemia in rats following the administration of the plant extract suggested that the studied extract possesses antidiabetic effect. The extract of S. hispanica produced hypolipidemic effect with a significant lowering effect on plasma total cholesterol levels and increased on HDL-cholesterol levels. SHSAE was also able to enhance glucose tolerance using OGTT. Moreover, SHSAE possesses a potential antioxidant effect in vitro.</p><p><strong>Conclusion: </strong>In conclusion, this study demonstrates the antihyperglycemic and antilipidemic effects of SHSAE in rats.</p>","PeriodicalId":9535,"journal":{"name":"Cardiovascular and Hematological Agents in Medicinal Chemistry","volume":"20 1","pages":"60-66"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular and Hematological Agents in Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871525719666210112154340","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 4
Abstract
Aims: The study targeted to evaluate the antihyperglycemic activity of Salvia hispanica.
Background: Salvia hispanica L. (Lamiaceae) is a medicinal plant with many beneficial properties on human health.
Objective: This objective of the study was to investigate the antihyperglycemic effect of the aqueous extract of Salvia hispanica (S. hispanica) seeds and its capacity to improve lipid profile in normal and STZ-induced diabetic rats.
Material and methods: The seed aqueous extract of S. hispanica (SHSAE) at a dose of 100 mg/kg was administered orally in normal and diabetic rats. The effect of oral SHSAE treatment on blood glucose and lipid levels during 15 days was assessed in normal and streptozotocin-induced diabetic rats. The oral glucose tolerance test (OGTT) was carried out. The antioxidant activity of SHSAE was also examined.
Results: The decrease of glycemia in rats following the administration of the plant extract suggested that the studied extract possesses antidiabetic effect. The extract of S. hispanica produced hypolipidemic effect with a significant lowering effect on plasma total cholesterol levels and increased on HDL-cholesterol levels. SHSAE was also able to enhance glucose tolerance using OGTT. Moreover, SHSAE possesses a potential antioxidant effect in vitro.
Conclusion: In conclusion, this study demonstrates the antihyperglycemic and antilipidemic effects of SHSAE in rats.
目的:研究丹参的降血糖作用。背景:鼠尾草(Salvia hispanica L.)是一种对人体健康有益的药用植物。目的:研究鼠尾草种子水提物对正常及stz诱导的糖尿病大鼠的降血糖作用及其对血脂的改善作用。材料与方法:以100 mg/kg的剂量给药于正常大鼠和糖尿病大鼠。观察口服SHSAE对正常和链脲佐菌素诱导的糖尿病大鼠15 d血糖和血脂水平的影响。进行口服糖耐量试验(OGTT)。研究了SHSAE的抗氧化活性。结果:给药后大鼠血糖明显下降，提示所研究的植物提取物具有抗糖尿病作用。西班牙花提取物具有降血脂作用，显著降低血浆总胆固醇水平，提高高密度脂蛋白胆固醇水平。SHSAE还能够通过OGTT提高葡萄糖耐量。此外，SHSAE在体外具有潜在的抗氧化作用。结论:本研究证实了SHSAE对大鼠的降糖、降脂作用。
期刊介绍：
Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
