Interamerican Society of Cardiology (IASC) position statement: Chlorthalidone vs. thiazide-type diuretics

Anil Pareek, Franz H. Messerli, Gustavo Saravia, Ravi Tejraj Mehta
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引用次数: 1

Abstract

The Interamerican Society of Cardiology (IASC) Position Statement for hypertension management in Latin America is a practical and useful review of five different hypertension guidelines. Though, thiazide diuretics have been recommended as firstline option, the position statement needs to highlight differences within the thiazide class. Chlorthalidone is structurally and pharmacokinetically distinct from thiazide-type iuretics like hydrochlorothiazide with a longer half-life and 24-h anti-hypertensive effect. It has been shown to reduce cardiovascular morbidity and mortality in several landmark studies evaluating anti-hypertensives.

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美洲心脏病学会(IASC)立场声明:氯噻酮与噻嗪类利尿剂
美洲心脏病学会(IASC)关于拉丁美洲高血压管理的立场声明是对五种不同高血压指南的实用和有用的回顾。虽然,噻嗪类利尿剂已被推荐为一线选择,但立场声明需要强调噻嗪类药物之间的差异。氯噻酮在结构和药代动力学上不同于噻嗪类利尿剂,如氢氯噻嗪,具有较长的半衰期和24小时降压作用。在一些评估抗高血压的里程碑式研究中,它已被证明可以降低心血管发病率和死亡率。
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来源期刊
International Journal of Cardiology: Hypertension
International Journal of Cardiology: Hypertension Medicine-Cardiology and Cardiovascular Medicine
CiteScore
0.40
自引率
0.00%
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0
审稿时长
13 weeks
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