Dependence of the apparent bicarbonate space on initial plasma bicarbonate concentration and carbon dioxide tension in neonatal calves with diarrhea, acidemia, and metabolic acidosis.

Abstract

Background: Marked strong ion (metabolic) acidosis in neonatal diarrheic calves usually is corrected by IV administration of NaHCO₃ . The distribution space for IV-administered bicarbonate, called the apparent bicarbonate space (ABS), appears to depend on initial plasma bicarbonate concentration (cHCO₃ ) and varies considerably in calves.

Objective: To determine whether ABS was associated with initial plasma cHCO₃ and other acid-base variables.

Animals: Twenty-five neonatal diarrheic calves with acidemia and metabolic acidosis.

Methods: Prospective observational study using a convenience sample. Calves received NaHCO₃ (10 mmol/kg) and glucose (1.4 mmol/kg) IV in a crystalloid solution at 25 mL/kg over 60 minutes. The ABS (L/kg) was calculated at 4 time points over 2 hours after the end of the infusion. The relationship between ABS and initial acid-base variables was characterized using nonlinear, linear, and stepwise regression.

Results: The median value for ABS calculated from the initial plasma cHCO₃ increased from 0.53 L/kg (range, 0.40-0.79) at the end of IV infusion to 0.96 L/kg (range, 0.54-1.23) 120 minutes later. Data obtained at the end of infusion provided the best fit to initial plasma cHCO₃ and jugular venous blood Pco₂ , such that: ABS = 0.41 + 1.06/cHCO₃ and ABS = 0.87-0.0082 × Pco₂ .

Conclusions and clinical importance: The observed median value for ABS of 0.53 L/kg in our study was similar to the empirically used value of 0.6. However, ABS values varied widely and were increased in calves with severe metabolic acidosis. We therefore recommend calculating ABS using the initial plasma cHCO₃ or venous blood Pco₂ , if respective measurements are available.