Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2021-01-01 DOI:10.1177/15333175211006504

Hyo Geun Choi, Bum Jung Park, Jae Sung Lim, Song Yong Sim, Yoon Jung Jung, Suk Woo Lee

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Abstract

Objective: This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort.

Methods: From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI.

Results: The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women.

Conclusions: We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.

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带状疱疹不会增加神经退行性痴呆症的风险：一项病例对照研究

研究目的本研究通过全国样本队列评估神经退行性痴呆与带状疱疹感染（HZI）之间的关联：我们从韩国国民健康保险服务局开展的全国队列研究中提取了神经退行性痴呆症患者和 1:4 匹配对照参与者的数据，并在患者病史中搜索了 HZI：在痴呆症组中，HZI 的调整赔率（OR）为 0.90（95% CI = 0.84-0.97）。根据亚组分析，小于 80 岁组 HZI 的调整 OR 为 0.91（95% 置信区间 [CI] = 0.83-1.00），≥ 80 岁组为 0.88（95% CI = 0.78-1.00），男性为 0.77（95% CI = 0.66-0.89），女性为 0.96（95% CI = 0.88-1.05）：我们的结论是，HZI 不会增加任何年龄或任何性别的人患神经退行性痴呆症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.