Effects of Caffeic Acid Phenethyl Ester and Oxidative Stress Caused by the Exhaustion Exercise on Endotelial Damage.

Abstract

This study was aimed to examine the effects of caffeic acid phenethyl ester (CAPE) on endothelial dysfunction in rats with exercise-induced oxidative stress. Tests were performed on male (n=32) young adult Sprague-Dawley rats (12 weeks of age). The experimental animals were divided into four groups in equal numbers. Group 1: General control group; Group 2: Swimming control group. Group 3: CAPE supplemented general control group. Group 4: CAPE supplemented swimming group. Furthermore, animals used in the experiment were made to do exhaustion practice toward the end of the examination. Plasma and liver tissue asymmetric dimethylarginine (ADMA) concentrations were not significantly (p0.05) increased in rats with acute swimming exercise compared to controls. Blood and liver cytokines levels were expanded in comparison to control group and CAPE groups (p0.05). Total antioxidant status (TAS) levels in acute swimming exercise groups reduced compared to the control group. Besides, total oxidant status (TOS) levels were considerably elevated compared to the control and CAPE groups. In this study, acute swimming exercise induced that oxidative stress could cause early onset of endothelial damage. Besides, CAPE can demonstrate protective effects on endothelial damage, inflammation and oxidative stress axis.