M1 Macrophages Are More Susceptible to Necroptosis.

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引用次数: 3

Abstract

Macrophages play a crucial role in host innate immune defense against infection and tissue injury. Although macrophage activation and polarization has been well studied, we know less regarding the role of macrophage activation/polarization in inflammation-associated necrotic cell death. By using bone marrow-derived macrophages, we have recently demonstrated that M1 macrophages are much more susceptible than M0 and M2 subtypes of macrophages to necrotic cell death. Moreover, we showed that the enhanced necroptosis in M1 macrophages is dependent on the kinase activity of receptor-interacting protein kinase-3 (RIPK3) and may involve the upregulation of key necroptosis signaling molecules including RIPK3, mixed lineage kinase domain-like protein, and Z-DNA/ RNA binding protein 1. Our findings provide novel insights into the mechanisms of M1 macrophage engagement in inflammation and tissue injury.

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M1巨噬细胞更容易发生坏死。
巨噬细胞在宿主抗感染和组织损伤的先天免疫防御中起着至关重要的作用。虽然巨噬细胞的活化和极化已经被研究得很好,但我们对巨噬细胞活化/极化在炎症相关坏死细胞死亡中的作用知之甚少。通过使用骨髓来源的巨噬细胞,我们最近证明M1巨噬细胞比M0和M2亚型的巨噬细胞更容易坏死细胞死亡。此外,我们发现M1巨噬细胞中坏死坏死的增强依赖于受体相互作用蛋白激酶-3 (RIPK3)的激酶活性,并可能涉及包括RIPK3、混合谱系激酶结构域样蛋白和Z-DNA/ RNA结合蛋白1在内的关键坏死坏死信号分子的上调。我们的发现为M1巨噬细胞参与炎症和组织损伤的机制提供了新的见解。
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