Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, Jennifer R Gamble
{"title":"The aging endothelium.","authors":"Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, Jennifer R Gamble","doi":"10.1530/VB-20-0013","DOIUrl":null,"url":null,"abstract":"<p><p>Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases.</p>","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"3 1","pages":"R35-R47"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052565/pdf/","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vascular biology (Bristol, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1530/VB-20-0013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
