A comparative efficacy test of 1 versus 2 doses of CIRCOQ PCV2 subunit vaccine against naturally occurring PCV2-type d in piglets with high maternally derived antibodies (MDAs) on a Vietnamese swine farm.

IF 1.1 4区 农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2021-04-01
Duy Tien Do, Khanh Doan Vinh Tran, Anh Tuyet Quach, David Lee, Frank Cj Chang, Carol Py Wu, Toan Nguyen Tat, Chanhee Chae
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Abstract

The aim of this study was to evaluate the protective efficacy of the CIRCOQ porcine circovirus type 2 (PCV2) subunit vaccine in piglets with high maternally derived antibodies (MDAs) against disease caused by natural infection with PCV2d. A total of 130 weaned, 21-day-old healthy pigs was allocated into 3 trial groups. The signs of respiratory disorder were higher in unvaccinated pigs than in vaccinated pigs at 13 to 17 weeks old (P < 0.05), 18 to 22 weeks old (P < 0.001), and 23 to 27 weeks old (P < 0.01). The unvaccinated pigs had an early rate of dermatitis at 8 to 12 weeks old (10.0%), 13 to 17 weeks old (30.0%), 18 to 22 weeks old (46.7%), and 23 to 27 weeks old (33.3%), while there were no cases of dermatitis in vaccinated pigs. There was a significant difference (P < 0.05) in the mortality of pigs in the unvaccinated group and the 2-dosed vaccinated group. PCV2 viremia was detected in the blood and peaked at 105 days old in both unvaccinated pigs (Ct-adj = 8.40) and pigs vaccinated with 1 dose (Ct-adj = 6.37), while no detectable PCV2 virus was found in the blood of pigs vaccinated with 2 doses. At 77 and 105 days old, the PCV2 viremia load (Ct-adj) of unvaccinated pigs and those vaccinated with 1 dose was significantly higher (P < 0.05) than that of the 2-dosed vaccinated pigs. The body weight (BW), average weight gain (AWG), and average daily gain (ADG) in both groups of vaccinated pigs were significantly higher (P < 0.05) than those of unvaccinated pigs. The study vaccine was significantly efficacious in protecting vaccinated pigs against clinical symptoms, blood viral load, and mortality, as well as improving productivity, compared with unvaccinated pigs.

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在越南养猪场进行了1剂和2剂CIRCOQ PCV2亚单位疫苗对具有高母源性抗体(mda)的仔猪天然发生的PCV2- d型的比较效力试验。
本研究的目的是评价CIRCOQ猪圆环病毒2型(PCV2)亚单位疫苗在具有高母源性抗体(mda)的仔猪中对自然感染PCV2d引起的疾病的保护作用。试验选用130头21日龄健康断奶仔猪,分为3个试验组。13 ~ 17周龄、18 ~ 22周龄和23 ~ 27周龄未接种猪的呼吸系统疾病症状均高于接种猪(P < 0.05)。未接种疫苗的猪在8 ~ 12周龄(10.0%)、13 ~ 17周龄(30.0%)、18 ~ 22周龄(46.7%)和23 ~ 27周龄(33.3%)有早期皮炎发生率,而接种疫苗的猪无皮炎病例。未接种组与2次接种组猪的死亡率差异有统计学意义(P < 0.05)。未接种疫苗的猪(Ct-adj = 8.40)和接种1剂疫苗的猪(Ct-adj = 6.37)血液中均检测到PCV2病毒血症,并在105日龄时达到高峰,而接种2剂疫苗的猪血液中未检测到PCV2病毒。77日龄和105日龄时,未接种和接种1剂的猪PCV2病毒载量(Ct-adj)显著高于接种2剂的猪(P < 0.05)。两组接种组猪的体重(BW)、平均增重(AWG)和平均日增重(ADG)均显著高于未接种组(P < 0.05)。与未接种疫苗的猪相比,该研究疫苗在保护接种疫苗的猪免受临床症状、血液病毒载量和死亡率的影响以及提高生产力方面显着有效。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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