Physical exercise increases peripheral brain-derived neurotrophic factors in patients with cognitive impairment: A meta-analysis.

IF 1.9 4区医学 Q4 NEUROSCIENCES Restorative neurology and neuroscience Pub Date : 2021-01-01 DOI:10.3233/RNN-201060

Hong Huang, Wenyang Li, Zheng Qin, Hui Shen, Xiaomeng Li, Wei Wang

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引用次数: 8

Abstract

Background: Physical exercise can improve cognitive dysfunction. Its specific mechanism remains unknown. Recent studies have indicated that elevating or peripherally overexpressing brain-derived neurotrophic factors (BDNF) improve cognitive impairment.

Objective: This meta-analysis aimed to investigate whether physical exercise improves cognitive performance in patients with cognitive dysfunction, such as mild cognitive impairment (MCI) or Alzheimer's disease (AD), by increasing peripheral BDNF.

Methods: PubMed, Embase, Cochrane Library, and Web of Science were searched up to June 2020 for studies that assayed the changes in peripheral BDNF levels in MCI and AD patients after exercise training.

Results: Peripheral BDNF levels were significantly elevated after a single exercise session (SMD = 0.469, 95% CI: 0.150-0.787, P = 0.004) or regular exercise interventions (SMD = 0.418, 95% CI: 0.105-0.731, P = 0.009). Subgroup analysis showed that only regular aerobic exercise interventions (SMD = 0.543, 95% CI: 0.038-1.049, P = 0.035) and intervention duration of 16 weeks or greater (SMD = 0.443, 95% CI: 0.154 -0.733, P = 0.003) significantly increased peripheral BDNF levels. Only plasma BDNF levels (SMD = 0.365, 95% CI:0.066-0.664, P = 0.017) were significantly increased after exercise interventions.

Conclusions: Acute and chronic physical exercises may improve cognitive impairment by increasing peripheral BDNF levels. Aerobic exercises and a longer duration of exercising increased BDNF levels. These findings also suggest that BDNF may be a suitable biomarker for evaluating the effect of exercise in patients with cognitive impairment, such as AD or MCI.

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体育锻炼增加认知障碍患者的外周脑源性神经营养因子:一项荟萃分析。

背景:体育锻炼可以改善认知功能障碍。其具体机制尚不清楚。最近的研究表明，脑源性神经营养因子(BDNF)的升高或周围过表达可改善认知障碍。目的:本荟萃分析旨在研究体育锻炼是否通过增加外周BDNF来改善认知功能障碍患者的认知表现，如轻度认知障碍(MCI)或阿尔茨海默病(AD)。方法:检索截至2020年6月的PubMed、Embase、Cochrane Library和Web of Science，以分析运动训练后MCI和AD患者外周血BDNF水平变化的研究。结果:单次运动(SMD = 0.469, 95% CI: 0.150-0.787, P = 0.004)或定期运动干预(SMD = 0.418, 95% CI: 0.105-0.731, P = 0.009)后，外周BDNF水平显著升高。亚组分析显示，只有常规有氧运动干预(SMD = 0.543, 95% CI: 0.038-1.049, P = 0.035)和干预时间≥16周(SMD = 0.443, 95% CI: 0.154 -0.733, P = 0.003)可显著增加外周BDNF水平。运动干预后，只有血浆BDNF水平(SMD = 0.365, 95% CI:0.066 ~ 0.664, P = 0.017)显著升高。结论:急性和慢性体育锻炼可能通过增加外周BDNF水平改善认知障碍。有氧运动和较长时间的运动增加了BDNF水平。这些发现还表明，BDNF可能是评估认知障碍(如AD或MCI)患者运动效果的合适生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Restorative neurology and neuroscience 医学-神经科学

CiteScore

5.40

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： This interdisciplinary journal publishes papers relating to the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers. Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.