Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2021-12-01 DOI:10.1080/13510002.2021.1927396

Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M Alsaffar, Showkat Ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali

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引用次数: 3

Abstract

Objectives: The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats.

Methods: PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated.

Results: Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst.

Conclusion: The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.

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山茱萸、大黄对来曲唑诱导的Wistar大鼠多囊卵巢综合征的改善作用。

目的:本研究旨在探讨虎尾草(CRE)和芍药(PGE)水醇提取物对来曲唑(1mg /kg)诱导的雌性Wistar白化大鼠多囊卵巢综合征(PCOS)的治疗作用。方法:将PCOS大鼠分别给予CRE (280 mg/kg)、PGE (140 mg/kg)或CRE + PGE p.o.治疗3周。研究了阴道涂片测定发情周期、血清雄激素水平、脂质谱、氧化应激参数和卵巢组织病理学。结果:CRE (III组)或PGE (IV组)治疗的发情周期天数明显减少(p p)结论:CRE和PGE单独或联合用药对来曲唑诱导的PCOS大鼠模型均有显著影响，可用于PCOS相关生殖和代谢障碍的治疗。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.