Prevalence and Associated Factors of Dyslipidemia Among Psychiatric Patients on Antipsychotic Treatment at Hawassa University Comprehensive Specialized Hospital.

IF 2.3 Q3 NUTRITION & DIETETICS Nutrition and Metabolic Insights Pub Date : 2021-05-17 eCollection Date: 2021-01-01 DOI:10.1177/11786388211016842

Agete Tadewos Hirigo, Tesfaye Teshome, Wondwossen Abera Gitore, Endale Worku

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引用次数: 6

Abstract

Background: Dyslipidemia is one of the adverse metabolic outcomes associated with psychotropic medications and the nature of the mental illness itself. Therefore, this study aimed to assess magnitude of dyslipidemia and associated factors among patients with severe mental illness on antipsychotic treatments.

Methods: A cross-sectional study was conducted among 245 patients with severe mental illness in Hawassa University Comprehensive Specialized Hospital, Sidama Regional state, Southern Ethiopia. Socio-demographic and other important data were collected using a structured questionnaire through a systematic random sampling technique. Individual dyslipidemia was characterized by the National Cholesterol Education Program Adult Treatment Panel-III (NCEP ATP-III) guideline.

Results: Mean total cholesterol (TC) was significantly higher in males when compared to females (162.2 mg/dl vs 121 mg/dl, P = .023). While, mean LDL-cholesterol was significantly higher in females when compared to males (100.9 mg/dl vs 93.6 mg/dl, P = .028). Overall 58.4% (95% CI: 52.2-64.8) of participants had at least 1 dyslipidemia. The prevalence of TC ⩾200 mg/dl, HDL-cholesterol <40 mg/dl, triglyceride (TG) and LDL-cholesterol were 61 (24.9%), 75 (30.6%), 66 (26.9%), and 47 (19.2%), respectively. Female sex and smoking were significantly and positively associated with LDL-c dyslipidemia, the aOR (95% CI) were 2.1 (1.0-4.2) for female sex and 3.4 (1.1-10.5) for smoking. Also, Age >40 years was significantly associated with TC dyslipidemia, the aOR (95% CI) was 2.0 (1.1-3.7).

Conclusion: More than half of psychiatric patients are at risk of developing cardiovascular and other related health problems. Therefore, periodic screening of lipid profiles during healthcare follow-up is mandatory to limit risks of cardiovascular-related comorbidities among patients with severe mental illness.

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阿瓦萨大学综合专科医院接受抗精神病药物治疗的精神病患者血脂异常患病率及相关因素分析

背景:血脂异常是与精神药物和精神疾病本身有关的不良代谢结果之一。因此，本研究旨在评估严重精神疾病患者在抗精神病药物治疗中的血脂异常程度及其相关因素。方法:对埃塞俄比亚南部西达马州阿瓦萨大学综合专科医院245例重度精神疾病患者进行横断面研究。通过系统的随机抽样技术，使用结构化问卷收集社会人口统计和其他重要数据。根据美国国家胆固醇教育计划成人治疗小组iii (NCEP ATP-III)指南，个体血脂异常具有特征。结果:男性的平均总胆固醇(TC)明显高于女性(162.2 mg/dl vs 121 mg/dl, P = 0.023)。而女性的平均低密度脂蛋白胆固醇明显高于男性(100.9 mg/dl vs 93.6 mg/dl, P = 0.028)。总体而言，58.4% (95% CI: 52.2-64.8)的参与者至少有1种血脂异常。TC小于200 mg/dl, 40年hdl -胆固醇的患病率与TC血脂异常显著相关，aOR (95% CI)为2.0(1.1-3.7)。结论:半数以上的精神病患者存在发生心血管和其他相关健康问题的风险。因此，在医疗随访期间定期筛查脂质谱是强制性的，以限制严重精神疾病患者心血管相关合并症的风险。

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来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.