Whole-brain 3D MR fingerprinting brain imaging: clinical validation and feasibility to patients with meningioma.

Abstract

Purpose: MR fingerprinting (MRF) is a MR technique that allows assessment of tissue relaxation times. The purpose of this study is to evaluate the clinical application of this technique in patients with meningioma.

Materials and methods: A whole-brain 3D isotropic 1mm³ acquisition under a 3.0T field strength was used to obtain MRF T₁ and T₂-based relaxometry values in 4:38 s. The accuracy of values was quantified by scanning a quantitative MR relaxometry phantom. In vivo evaluation was performed by applying the sequence to 20 subjects with 25 meningiomas. Regions of interest included the meningioma, caudate head, centrum semiovale, contralateral white matter and thalamus. For both phantom and subjects, mean values of both T₁ and T₂ estimates were obtained. Statistical significance of differences in mean values between the meningioma and other brain structures was tested using a Friedman's ANOVA test.

Results: MR fingerprinting phantom data demonstrated a linear relationship between measured and reference relaxometry estimates for both T₁ (r² = 0.99) and T₂ (r² = 0.97). MRF T₁ relaxation times were longer in meningioma (mean ± SD 1429 ± 202 ms) compared to thalamus (mean ± SD 1054 ± 58 ms; p = 0.004), centrum semiovale (mean ± SD 825 ± 42 ms; p < 0.001) and contralateral white matter (mean ± SD 799 ± 40 ms; p < 0.001). MRF T₂ relaxation times were longer for meningioma (mean ± SD 69 ± 27 ms) as compared to thalamus (mean ± SD 27 ± 3 ms; p < 0.001), caudate head (mean ± SD 39 ± 5 ms; p < 0.001) and contralateral white matter (mean ± SD 35 ± 4 ms; p < 0.001) CONCLUSIONS: Phantom measurements indicate that the proposed 3D-MRF sequence relaxometry estimations are valid and reproducible. For in vivo, entire brain coverage was obtained in clinically feasible time and allows quantitative assessment of meningioma in clinical practice.