Bioinspired double self-adhesion coating based on dopamine, coating resin and phosphorylcholine for surface lubrication and antifouling functionalization.

IF 1.8 4区 化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2021-04-22 DOI:10.1080/15685551.2021.1919389
Qipeng Li, Qiuxiang Yin, Baohong Hou, Ling Zhou
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Abstract

Implanted medical devices that have poor friction property or biofilm formation can limit their service life and cause discomfort in patients. Recently, some zwitterionic coatings have been studied to modify the biomaterials surface for lubricating function, but the grafting methods of coatings are complicated and also seldom take the bacterial antiadhesion property into account at the same time. In our studies, motivated by the properties of nature mussels and human articular, we firstly successfully synthesized double adhesion protection of self-adhesive ternary polymer coating and achieved the excellent lubrication and antifouling functionalization of the medical devices surface. In details, the X-ray photoelectron spectroscopy, scanning electron microscope and the water contact angles could characterize the successful modification on the surface of titanium substrate. Additionally, the tribological tests carried out by atomic force microscope verified the ternary polymer could enhance the lubrication property owing to the hydration lubrication mechanism. Meanwhile, it also possessed the bacterial antiadhesion property for the initial 24 h attributed to the hydration repulsive force. We believe that, as a simple and universal preparation method, the ternary polymer could make a great significance for improving the surface function of biomaterials and alleviating patients' discomfort.

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基于多巴胺、涂层树脂和磷胆碱的仿生双自粘涂层,用于表面润滑和防污功能化。
植入式医疗器械摩擦性能差或形成生物膜会限制其使用寿命,并引起患者不适。近年来,人们研究了一些两性离子涂层来修饰生物材料的表面,使其具有润滑功能,但涂层的接枝方法复杂,同时也很少考虑到细菌的抗粘附性。在我们的研究中,我们以自然贻贝和人体关节的特性为动力,首次成功合成了双粘附保护的自粘三元聚合物涂层,实现了医疗器械表面优异的润滑和防污功能化。x射线光电子能谱、扫描电镜和水接触角表征了钛基表面改性的成功进行。原子力显微镜下的摩擦学试验验证了三元聚合物由于水化润滑机制而提高了润滑性能。同时,由于水合斥力的作用,在初始24 h内还具有抗细菌粘附性能。我们认为,三元聚合物作为一种简单通用的制备方法,对于改善生物材料的表面功能,减轻患者的不适具有重要意义。
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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
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