Pharmacokinetics Parameters of Diagoxin among Saudi Patients in Qassim Region, Saudi Arabia.

Drug metabolism letters Pub Date : 2021-01-01 DOI:10.2174/1872312814666210506121637

Abdulaziz S Allihimy, Ahmad A Almeman, Nassar A Alnassar, Jihad Almadhi

{"title":"Pharmacokinetics Parameters of Diagoxin among Saudi Patients in Qassim Region, Saudi Arabia.","authors":"Abdulaziz S Allihimy, Ahmad A Almeman, Nassar A Alnassar, Jihad Almadhi","doi":"10.2174/1872312814666210506121637","DOIUrl":null,"url":null,"abstract":"Background: The pharmacodynamic effects of digoxin are susceptible to multiple factors, most notably, heart uptake of the digoxin dose and its concentration in the serum. Another important factor to mention is the renal function state of an individual.Objective: In this study, we aimed to develop a simple algorithm based on subsets of clinically relevant information, which will help to personalize digoxin based on pharmacokinetic (PK) approach which can help in marketing the appropriate utilization of this medication.Methods: This was a retrospective chart review and analysis of 48 patients who were admitted to the Drug and Poison Information center in Buraidah, Saudi Arabia, between January 2016 and April 2019. All pharmacokinetic parameters were added according to the C-peaks and C-troughs. MONOLiX® was used for data pharmacokinetic analysis.Results: Twenty-seven (56%) were males and twenty-one (44%) were females with an average age of 63.6 years across both genders. The mean volume of distribution was 496.6 litres with an average clearance of 6.6 L/h. For females, their average volume of distribution was slightly higher than that for males (526 litres compared to 473 litres). In addition, the clearance rate between both genders showed a 2.1 litre/hour discrepancy (7.8 L/h for females compared to 5.7 L/h for males).Conclusion: In order to individualize the digoxin dosage regimens, this model can be used to predict digoxin serum concentration. Further studies are needed to clarify the effects of nutritional status and co-administration of medications on digoxin pharmacokinetics.","PeriodicalId":11339,"journal":{"name":"Drug metabolism letters","volume":"14 2","pages":"137-140"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug metabolism letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1872312814666210506121637","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The pharmacodynamic effects of digoxin are susceptible to multiple factors, most notably, heart uptake of the digoxin dose and its concentration in the serum. Another important factor to mention is the renal function state of an individual.

Objective: In this study, we aimed to develop a simple algorithm based on subsets of clinically relevant information, which will help to personalize digoxin based on pharmacokinetic (PK) approach which can help in marketing the appropriate utilization of this medication.

Methods: This was a retrospective chart review and analysis of 48 patients who were admitted to the Drug and Poison Information center in Buraidah, Saudi Arabia, between January 2016 and April 2019. All pharmacokinetic parameters were added according to the C-peaks and C-troughs. MONOLiX® was used for data pharmacokinetic analysis.

Results: Twenty-seven (56%) were males and twenty-one (44%) were females with an average age of 63.6 years across both genders. The mean volume of distribution was 496.6 litres with an average clearance of 6.6 L/h. For females, their average volume of distribution was slightly higher than that for males (526 litres compared to 473 litres). In addition, the clearance rate between both genders showed a 2.1 litre/hour discrepancy (7.8 L/h for females compared to 5.7 L/h for males).

Conclusion: In order to individualize the digoxin dosage regimens, this model can be used to predict digoxin serum concentration. Further studies are needed to clarify the effects of nutritional status and co-administration of medications on digoxin pharmacokinetics.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

沙特阿拉伯卡西姆地区沙特患者对角辛的药动学参数

背景:地高辛的药效学效应受多种因素的影响，最明显的是地高辛的心脏吸收剂量及其在血清中的浓度。另一个需要提及的重要因素是个人的肾功能状态。目的:在本研究中，我们旨在开发一种基于临床相关信息子集的简单算法，该算法将有助于基于药代动力学(PK)方法的地高辛个体化，从而有助于该药物的合理使用。方法:对2016年1月至2019年4月在沙特阿拉伯Buraidah药物和毒物信息中心入院的48例患者进行回顾性图表回顾和分析。根据c -峰和c -谷添加所有药动学参数。使用MONOLiX®进行数据药代动力学分析。结果:男性27例(56%)，女性21例(44%)，男女平均年龄63.6岁。平均分布容积为496.6升，平均清除率为6.6升/小时。女性的平均分配体积略高于男性(526升对473升)。此外，两性之间的清除率差异为2.1升/小时(女性为7.8升/小时，男性为5.7升/小时)。结论:该模型可用于地高辛血药浓度的预测，为地高辛给药方案的个体化提供依据。需要进一步的研究来阐明营养状况和联合用药对地高辛药代动力学的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Drug metabolism letters Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

自引率

0.00%

发文量

期刊介绍： Drug Metabolism Letters publishes letters and research articles on major advances in all areas of drug metabolism and disposition. The emphasis is on publishing quality papers very rapidly by taking full advantage of the Internet technology both for the submission and review of manuscripts. The journal covers the following areas: In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites.