Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-05-12 DOI:10.1080/10641955.2021.1921791

Petar Cabunac, Nataša Karadžov Orlić, Daniela Ardalić, Barbara Damnjanović Pažin, Srđan Stanimirović, Gorica Banjac, Aleksandra Stefanović, Vesna Spasojević-Kalimanovska, Amira Egić, Nina Rajović, Nataša Milić, Željko Miković

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引用次数: 3

Abstract

OBJECTIVE: This study aimed to assess the accuracy of The Fetal Medicine Foundation (FMF) screening algorithm for the prediction of preeclampsia.METHODS: Out of 138 women with high-risk pregnancies prospectively followed, 30 developed preeclampsia. The clinical examination and biochemical measurements were performed at first, second, early and late third trimester.RESULTS: A lower PAPP-A levels were found in the first trimester, while sFlt/PlGF was increased in the second and early third trimester in preeclampsia (p>0.05). FMF algorithm presented higher specificity (>70%), but had a drawback of lower sensitivity (35-77%).CONCLUSION: FMF algorithm had modest performance in the prediction of preeclampsia for high-risk pregnancies.

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使用FMF算法预测高危妊娠子痫前期:单中心纵向研究

目的:本研究旨在评估胎儿医学基金会(FMF)筛选算法预测子痫前期的准确性。方法:对138名高危妊娠妇女进行前瞻性随访，其中30名出现先兆子痫。分别于妊娠早期、中期、早期和晚期进行临床检查和生化指标测定。结果:子痫前期患儿PAPP-A水平较低，而sFlt/PlGF水平在妊娠中期和妊娠晚期早期升高(p>0.05)。FMF算法具有较高的特异性(>70%)，但灵敏度较低(35-77%)。结论:FMF算法对高危妊娠子痫前期的预测效果一般。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.