A Review of the Antimicrobial Activity of Selenium Nanoparticles.

Fernando Martínez-Esquivias, Juan Manuel Guzmán-Flores, Alejandro Pérez-Larios, Napoleón González Silva, Julieta Saraí Becerra-Ruiz
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引用次数: 9

Abstract

Antimicrobial resistance has become a severe problem for health systems worldwide, and counteractions are challenging because of the lack of interest of pharmaceutical companies in generating new and effective antimicrobial drugs. Selenium nanoparticles have attracted considerable interest in treating bacteria, fungi, parasites, and viruses of clinical importance due to their high therapeutic efficacy and almost zero generation of adverse effects. Some studies have revealed that the antimicrobial activity of these nanoparticles is due to the generation of reactive oxygen species, but more studies are needed to clarify their antimicrobial mechanisms. Other studies show that their antimicrobial activity is increased when the surface of the nanoparticles is functionalized with some biomolecules or when their surface carries a specific drug. This review addresses the existing background on the antimicrobial potential offered by selenium nanoparticles against viruses, bacteria, fungi, and parasites of clinical importance.

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纳米硒抗菌活性研究进展
抗菌素耐药性已成为世界各地卫生系统面临的一个严重问题,由于制药公司对开发新的有效抗菌素药物缺乏兴趣,因此应对措施具有挑战性。硒纳米颗粒由于其高疗效和几乎零副作用的产生,在治疗具有临床重要性的细菌、真菌、寄生虫和病毒方面引起了相当大的兴趣。一些研究表明,这些纳米颗粒的抗菌活性是由于活性氧的产生,但需要更多的研究来阐明其抗菌机制。其他研究表明,当纳米颗粒表面与某些生物分子功能化或其表面携带特定药物时,其抗菌活性会增加。本文综述了纳米硒对病毒、细菌、真菌和寄生虫的抗菌潜力的现有背景,具有临床意义。
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来源期刊
Journal of nanoscience and nanotechnology
Journal of nanoscience and nanotechnology 工程技术-材料科学:综合
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审稿时长
3.6 months
期刊介绍: JNN is a multidisciplinary peer-reviewed journal covering fundamental and applied research in all disciplines of science, engineering and medicine. JNN publishes all aspects of nanoscale science and technology dealing with materials synthesis, processing, nanofabrication, nanoprobes, spectroscopy, properties, biological systems, nanostructures, theory and computation, nanoelectronics, nano-optics, nano-mechanics, nanodevices, nanobiotechnology, nanomedicine, nanotoxicology.
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