Distinct behavioral traits and associated brain regions in mouse models for obsessive-compulsive disorder.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2021-05-18 DOI:10.1186/s12993-021-00177-x
Xiao Chen, Jihui Yue, Yuchong Luo, Lianyan Huang, Boxing Li, Shenglin Wen
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引用次数: 6

Abstract

Background: Obsessive-compulsive disorder (OCD) is a mental disease with heterogeneous behavioral phenotypes, including repetitive behaviors, anxiety, and impairments in cognitive functions. The brain regions related to the behavioral heterogeneity, however, are unknown.

Methods: We systematically examined the behavioral phenotypes of three OCD mouse models induced by pharmacological reagents [RU24969, 8-hydroxy-DPAT hydrobromide (8-OH-DPAT), and 1-(3-chlorophenyl) piperazine hydrochloride-99% (MCPP)], and compared the activated brain regions in each model, respectively.

Results: We found that the mouse models presented distinct OCD-like behavioral traits. RU24969-treated mice exhibited repetitive circling, anxiety, and impairments in recognition memory. 8-OH-DPAT-treated mice exhibited excessive spray-induced grooming as well as impairments in recognition memory. MCPP-treated mice showed only excessive self-grooming. To determine the brain regions related to these distinct behavioral traits, we examined c-fos expression to indicate the neuronal activation in the brain. Our results showed that RU24969-treated mice exhibited increased c-fos expression in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), prelimbic cortex (PrL), infralimbic cortex (IL), nucleus accumbens (NAc), hypothalamus, bed nucleus of the stria terminalis, lateral division, intermediate part (BSTLD), and interstitial nucleus of the posterior limb of the anterior commissure, lateral part (IPACL), whereas in 8-OH-DPAT-treated mice showed increased c-fos expression in the ACC, PrL, IL, OFC, NAc shell, and hypothalamus. By contrast, MCPP did not induce higher c-fos expression in the cortex than control groups.

Conclusion: Our results indicate that different OCD mouse models exhibited distinct behavioral traits, which may be mediated by the activation of different brain regions.

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强迫症小鼠模型中不同的行为特征和相关的大脑区域。
背景:强迫症(Obsessive-compulsive disorder, OCD)是一种具有异质性行为表型的精神疾病,包括重复行为、焦虑和认知功能障碍。然而,与行为异质性相关的大脑区域尚不清楚。方法:系统检测药理学试剂RU24969、8-羟基- dpat氢溴化物(8-OH-DPAT)和1-(3-氯苯基)哌嗪-99% (MCPP)诱导的3种强迫症小鼠模型的行为表型,并分别比较各模型的激活脑区。结果:我们发现小鼠模型表现出明显的强迫症样行为特征。ru24969治疗小鼠表现出重复打圈、焦虑和识别记忆损伤。8- oh - dpat处理的小鼠表现出过度的喷雾诱导的梳理以及识别记忆的损伤。mcpp处理的小鼠只表现出过度的自我梳理。为了确定与这些不同行为特征相关的大脑区域,我们检查了c-fos表达以指示大脑中的神经元激活。我们的研究结果表明,ru24969处理的小鼠在眶额皮质(OFC)、前扣带皮质(ACC)、边缘前皮质(PrL)、边缘下皮质(IL)、伏隔核(NAc)、下丘脑、终纹床核、外侧分割、中间部分(BSTLD)和前联合后肢外侧部分(IPACL)的c-fos表达增加,而8- oh - dpat处理的小鼠在ACC中c-fos表达增加。PrL, IL, OFC, NAc壳和下丘脑。相比之下,MCPP并没有诱导皮层中c-fos的表达高于对照组。结论:不同强迫症小鼠模型表现出不同的行为特征,这可能与不同脑区的激活有关。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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