The interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Thyroid Research Pub Date : 2021-05-25 DOI:10.1186/s13044-021-00102-4

Stine Linding Andersen, Kasper Krogh Nielsen, Søren Risom Kristensen

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引用次数: 1

Abstract

Pregnancy induces physiological changes that affect the risk of thrombosis and thyroid disease. In this hypothesis-generating review, the physiological changes in the coagulation system and in thyroid function during a normal pregnancy are described, and the incidence of venous thromboembolism (VTE) and thyroid disease in and after a pregnancy are compared and discussed. Furthermore, evidence regarding the association between thyroid disease and VTE in non-pregnant individuals is scrutinized. In conclusion, a normal pregnancy entails hormonal changes, which influence the onset of VTE and thyroid disease. Current evidence suggests an association between thyroid disease and VTE in non-pregnant individuals. This review proposes the hypothesis that maternal thyroid disease associates with VTE in pregnant women and call for future research studies on this subject. If an association exists in pregnant women specifically, such findings may have clinical implications regarding strategies for thyroid function testing and potential thromboprophylaxis in selected individuals.

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妊娠、静脉血栓栓塞和甲状腺疾病之间的相互关系:一项假设生成综述。

妊娠引起的生理变化会影响血栓形成和甲状腺疾病的风险。在这篇产生假设的综述中，描述了正常妊娠期间凝血系统和甲状腺功能的生理变化，并比较和讨论了妊娠期间和妊娠后静脉血栓栓塞(VTE)和甲状腺疾病的发病率。此外，关于甲状腺疾病和静脉血栓栓塞在非怀孕个体之间的关系的证据被仔细审查。综上所述，正常妊娠伴随着激素变化，而激素变化会影响静脉血栓栓塞和甲状腺疾病的发生。目前的证据表明，在非怀孕个体甲状腺疾病和静脉血栓栓塞之间存在关联。本文提出了母体甲状腺疾病与孕妇静脉血栓栓塞相关的假设，并呼吁对这一主题进行进一步的研究。如果这种关联存在于孕妇中，这些发现可能对选定个体的甲状腺功能检测和潜在的血栓预防策略具有临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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