Does the number of doses matter? A qualitative study of HPV vaccination acceptability nested in a dose reduction trial in Tanzania

IF 4.7 Q1 VIROLOGY Tumour Virus Research Pub Date : 2021-12-01 DOI:10.1016/j.tvr.2021.200217
K.R. Mitchell , T. Erio , H.S. Whitworth , G. Marwerwe , J. Changalucha , K. Baisley , C.J. Lacey , R. Hayes , S. de SanJosé , D. Watson-Jones
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引用次数: 1

Abstract

Background

The multi-dose regimen is a known barrier to successful human papillomavirus (HPV) vaccination. Emerging evidence suggests that one vaccine dose could protect against HPV. While there are clear advantages to a single dose schedule, beliefs about vaccine dosage in low and middle income countries (LMICs) are poorly understood. We investigated acceptability of dose-reduction among girls, and parents/guardians of girls, randomised to receive one, two or three doses in an HPV vaccine dose-reduction and immunobridging study (DoRIS trial) in Tanzania.

Methods

Semi-structured interviews with girls (n = 19), and parents/guardians of girls (n = 18), enrolled in the study and completing their vaccine course.

Results

Most participants said they entrusted decisions about the number of HPV vaccine doses to experts. Random allocation to the different dose groups did not feature highly in the decision to participate in the trial. Given a hypothetical choice, girls generally said they would prefer fewer doses in order to avoid the pain of injections. Parental views were mixed, with most wanting whichever dose was most efficacious. Nonetheless, a few parents equated a higher number of doses with greater protection.

Conclusion

Vaccine trials and programmes will need to employ careful messaging to explain that one dose offers sufficient protection against HPV should emerging evidence from ongoing dose-reduction clinical trials support this.

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剂量多少重要吗?一项定性研究HPV疫苗接种可接受性嵌套在坦桑尼亚剂量减少试验
背景:多剂量方案是成功接种人乳头瘤病毒(HPV)疫苗的一个已知障碍。新出现的证据表明,一剂疫苗可以预防HPV。虽然单一剂量计划有明显的优势,但人们对低收入和中等收入国家的疫苗剂量知之甚少。在坦桑尼亚的一项HPV疫苗减剂量和免疫桥接研究(DoRIS试验)中,我们调查了女孩和女孩的父母/监护人对减剂量的接受程度,这些女孩被随机分为一剂、两剂或三剂。方法对参加研究并完成疫苗课程的女孩(n = 19)和女孩的父母/监护人(n = 18)进行半结构化访谈。结果大多数参与者表示,他们将HPV疫苗剂量的决定委托给专家。随机分配到不同剂量组在决定是否参加试验中没有很高的作用。在一个假设的选择中,女孩们普遍表示,为了避免注射的痛苦,她们更愿意少注射一些。家长们的意见不一,大多数人希望哪种剂量最有效。尽管如此,还是有一些家长认为,注射次数越多,保护作用就越大。结论:如果正在进行的减少剂量的临床试验中出现的证据支持这一点,疫苗试验和规划需要谨慎地传达信息,以解释一剂疫苗就能提供足够的预防HPV的保护。
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来源期刊
Tumour Virus Research
Tumour Virus Research Medicine-Infectious Diseases
CiteScore
6.50
自引率
2.30%
发文量
16
审稿时长
56 days
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