Validation of magnetic resonance relaxometry R2 value and cyst fluid iron level for diagnosis of ovarian endometrioma.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2021-12-01 DOI:10.1080/13510002.2021.1937456

Shogo Imanaka, Yuki Yamada, Naoki Kawahara, Hiroshi Kobayashi

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引用次数: 2

Abstract

Objectives: Magnetic resonance (MR) R2 relaxometry is a safe, noninvasive diagnostic modality for the evaluation of iron levels in the contents of ovarian cysts. The study aims to investigate the sensitivity and specificity of the two methods, R2 value and iron level, in diagnosing OMA patients in the validation set.

Methods: A prospective cohort study was conducted from 2013 to 2019. We investigated how R2 value was affected by iron-related compounds, antioxidants and bioelements in the cysts.

Results: The sensitivity and specificity of CF iron-based diagnosis of OMA was 96.6% and 95.4%, respectively. The sensitivity and specificity for R2 value in diagnosing OMA were 86.2% and 70.7%, respectively. The outcomes of the two tests were highly correlated (r = 0.758; P <0.001). The R2 value was positively correlated with CF levels of iron-related compounds and antioxidants. The R2 value was affected not only by iron ions but also by calcium ions.

Conclusion: Preoperative MR relaxometry may provide a noninvasive alternative to CF iron test in diagnosing OMA. The presence of paramagnetic cations in the cyst may be associated with reduced specificity.

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磁共振弛豫仪R2值和囊肿液铁水平诊断卵巢子宫内膜异位瘤的验证。

目的:磁共振(MR) R2弛豫仪是一种安全、无创的诊断方法，用于评估卵巢囊肿内容物中的铁水平。本研究旨在探讨验证集中R2值和铁水平两种方法诊断OMA患者的敏感性和特异性。方法:2013 - 2019年进行前瞻性队列研究。我们研究了囊内铁相关化合物、抗氧化剂和生物元素对R2值的影响。结果:CF铁基诊断OMA的敏感性为96.6%，特异性为95.4%。R2值诊断OMA的敏感性为86.2%，特异性为70.7%。两项检测结果高度相关(r = 0.758;结论:术前磁共振弛豫仪可作为CF铁试验诊断OMA的无创替代方法。囊肿中顺磁性阳离子的存在可能与特异性降低有关。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.