Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement - a case series.

Abstract

High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL ${}^{-1}$ ) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.