Multiple novel functions of circular RNAs in diabetes mellitus.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-04 DOI:10.1080/13813455.2021.1933047

Sadra Samavarchi Tehrani, Golnaz Goodarzi, Ghodratollah Panahi, Mahmood Maniati, Reza Meshkani

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引用次数: 6

Abstract

Circular RNAs (circRNAs), as an emerging group of non-coding RNAs (ncRNAs), have received the attention given evidence indicating that these novel ncRNAs are implicated in various biological processes. Due to the absence of 5' and 3' ends in circ-RNAs, their two ends are covalently bonded together, and they are synthesised from pre-mRNAs in a process called back-splicing, which makes them more stable than linear RNAs. There is accumulating evidence showing that circRNAs play a critical role in the pathogenesis of diabetes mellitus (DM). Moreover, it has been indicated that dysregulation of circRNAs has made them promising diagnostic biomarkers for the detection of DM. Recently, increasing attention has been paid to investigate the mechanisms underlying the DM process. It has been demonstrated that there is a strong correlation between the expression of circRNAs and DM. Hence, our aim is to discuss the crosstalk between circRNAs and DM and its complications.

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环状rna在糖尿病中的多种新功能。

环状rna (circRNAs)作为一种新兴的非编码rna (ncRNAs)，已经受到了人们的关注，因为有证据表明这些新型的ncRNAs与各种生物过程有关。由于环状rna中没有5'和3'端，它们的两端是共价结合在一起的，它们是由pre- mrna在一个称为反剪接的过程中合成的，这使得它们比线性rna更稳定。越来越多的证据表明，环状rna在糖尿病(DM)的发病机制中起着关键作用。此外，研究表明，环状rna的失调使其成为检测糖尿病的有希望的诊断生物标志物。最近，人们越来越关注糖尿病过程的潜在机制。研究表明，circrna的表达与DM之间存在很强的相关性。因此，我们的目的是讨论circrna与DM之间的串扰及其并发症。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.