The evolution of the concept of stress and the framework of the stress system.

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2021-04-26 DOI:10.15698/cst2021.06.250
Siyu Lu, Fang Wei, Guolin Li
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引用次数: 47

Abstract

Stress is a central concept in biology and has now been widely used in psychological, physiological, social, and even environmental fields. However, the concept of stress was cross-utilized to refer to different elements of the stress system including stressful stimulus, stressor, stress response, and stress effect. Here, we summarized the evolution of the concept of stress and the framework of the stress system. We find although the concept of stress is developed from Selye's "general adaptation syndrome", it has now expanded and evolved significantly. Stress is now defined as a state of homeostasis being challenged, including both system stress and local stress. A specific stressor may potentially bring about specific local stress, while the intensity of stress beyond a threshold may commonly activate the hypothalamic-pituitary-adrenal axis and result in a systematic stress response. The framework of the stress system indicates that stress includes three types: sustress (inadequate stress), eustress (good stress), and distress (bad stress). Both sustress and distress might impair normal physiological functions and even lead to pathological conditions, while eustress might benefit health through hormesis-induced optimization of homeostasis. Therefore, an optimal stress level is essential for building biological shields to guarantee normal life processes.

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应力概念的演变和应力系统的框架。
压力是生物学中的一个核心概念,目前已广泛应用于心理、生理、社会甚至环境等领域。然而,压力的概念被交叉用来指压力系统的不同元素,包括压力刺激、压力源、压力反应和压力效应。本文综述了应力概念的演变和应力系统的框架。我们发现,虽然压力的概念是从Selye的“一般适应综合征”发展而来的,但它现在已经得到了显著的扩展和演变。压力现在被定义为一种自我平衡受到挑战的状态,包括系统压力和局部压力。特定的应激源可能带来特定的局部应激,而超过阈值的应激强度通常会激活下丘脑-垂体-肾上腺轴并导致系统性应激反应。应激系统的框架表明,应激包括三种类型:应激(不充分的应激)、应激(良好的应激)和应激(不良的应激)。压力和痛苦都可能损害正常的生理功能,甚至导致病理状况,而良性压力可能通过激效诱导的体内平衡优化而有益于健康。因此,一个最佳的压力水平是必不可少的建立生物屏障,以保证正常的生命过程。
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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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