Development of Pharyngocutaneous Fistula after Total Laryngectomy: The Predictive Value of C-reactive Protein/Albumin Ratio.

Q3 Medicine Acta medica (Hradec Kralove) Pub Date : 2020-01-01 DOI:10.14712/18059694.2020.58

Abitter Yücel, Hilal Yücel, Fuat Aydemir, Mert Mutaf, Mehmet Akif Eryılmaz, Hamdi Arbağ

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引用次数: 3

Abstract

Background: We aimed to evaluate whether C-reactive protein(CRP)/ Albumin ratio (CAR) performed in the early postoperative period after total laryngectomy could be a predictive factor for the development of pharyngocutaneous fistula (PCF).

Methods: The files of patients with laryngeal squamous cell carcinoma who underwent total laryngectomy between January 2005 and January 2019 were retrospectively reviewed. Patients were divided into two groups: patients with PCF (PCF group) and without (Non-PCF group). CAR values and risk factors were compared between groups.

Results: The overall incidence of PCF was 23.2%. There was a statistically significant difference between the two groups in terms of CRP and CAR levels (p = 0.001). The CAR value of 27.05 (sensitivity = 75.0% , specificity 68.2%, area under curve (AUC) = 0.742, 95% confidence interval 0.616-0.868) was determined as a cutoff value to describe the development of fistula in the early postoperative period. In multiple linear regression analysis, there was an independent relationship between presence of PCF and previous RT and CAR value.

Conclusions: CAR, performed in the early postoperative period, may be a new and useful marker for predicting PCF after total laryngectomy.

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全喉切除术后咽皮瘘的发生:c反应蛋白/白蛋白比值的预测价值。

背景:我们的目的是评估c反应蛋白(CRP)/白蛋白比(CAR)在全喉切除术术后早期是否可以作为咽皮瘘(PCF)发展的预测因素。方法:回顾性分析2005年1月至2019年1月行全喉切除术的喉鳞癌患者的资料。患者分为两组:有PCF组(PCF组)和无PCF组(Non-PCF组)。两组间CAR值及危险因素比较。结果:PCF总发病率为23.2%。两组患者CRP和CAR水平差异有统计学意义(p = 0.001)。CAR值为27.05(敏感性为75.0%，特异性为68.2%，曲线下面积(AUC) = 0.742, 95%可信区间为0.616-0.868)作为描述术后早期瘘发生的截断值。在多元线性回归分析中，PCF的存在与既往RT和CAR值之间存在独立关系。结论:CAR在术后早期进行，可能是预测全喉切除术后PCF的一种新的、有用的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta medica (Hradec Kralove) Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."