Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Insights Pub Date : 2021-06-04 eCollection Date: 2021-01-01 DOI:10.1177/11772719211021647
Katja Tromp, Philip van der Zee, Casper Rokx, Jeroen van Kampen, Diederik Gommers, Henrik Endeman
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引用次数: 2

Abstract

Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids.

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甲泼尼龙对重症COVID-19患者炎症和凝血的影响:一项回顾性队列研究
糖皮质类固醇降低了2019冠状病毒病(COVID-19)患者的死亡率。以前,我们假设皮质类固醇减轻炎症反应,从而减少凝血和血栓形成。在这项回顾性研究中,我们纳入了27例因持续呼吸衰竭或过度炎症反应而接受大剂量皮质类固醇(甲基强的松龙1000 mg每日静脉注射,持续3天)治疗的COVID-19患者。我们发现甲强的松龙治疗后炎症、凝血和通气参数明显改善。SARS-CoV-2病毒载量保持稳定或下降。这些结果为使用皮质类固醇治疗的COVID-19患者观察到的死亡率降低提供了见解。
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来源期刊
Biomarker Insights
Biomarker Insights MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.00
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
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